This book explains tumorigenic mechanisms underlying common cancers from different sites of the gut, using illustrations of important mechanisms and pathways. There is emphasis on the importance of stem cells and the spread of mutations during tumorigenesis. Photographs will be used to enable pathologists and other clinicians to relate histological appearances to underlying tumorigenic processes, thereby putting these appearances into context. The volume considers how current management regimes affect tumorigenesis and how an understanding of underlying mechanisms can lead to the development of new strategies for screening, diagnosis and therapy.
Introduction Adult Stem Cells; Common Tumorigenic Mutations in the GI Tract; The Oesophagus: Tumorigenic Pathways in the Oesophagus; Overview of Management of Oesophageal Adenocarcinoma; The Stomach Stem Cells of the Gastric Mucosa; Precursor Lesions of Gastric Adenocarcinoma; The Small Bowel Overview of Grading and Staging of Small Intestinal Adenocarcinoma; The Pancreas Stem Cells of the Pancreas; Tumorigenic Pathways in the Pancreas; Future Approaches to Screening, Diagnosis and Management; The Liver; The Large Bowel.
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