Contents of Volume 1 About the Editors, xiii List of Contributors, xv Preface to the Fourth Edition, xxiii Preface to the Fifth Edition, xxv Foreword, xxvii Introduction: Historical perspectives, 1 Michael J. Denham and John E. Morley Part 1 Ageing: Biological, Social and Community Perspectives 1 A biological perspective of ageing, 13 H. James Armbrecht 2 The demography of ageing, 23 Kenneth G. Manton and John E. Morley 3 The physiology of ageing, 33 Rafi T. Kevorkian and John E. Morley 4 Psychological aspects of ageing, 43 Peggy A. Szwabo 5 Ageing of the brain, 49 Jean-Franc,ois Demonet and Pierre Celsis 6 Epidemiology of ageing and disability, 55 Lenise A. Cummings-Vaughn 7 Social and community aspects of ageing, 67 John E. Morley and Nina Tumosa 8 The developmental origins of ageing, 81 Avan Aihie Sayer and Cyrus Cooper 9 Sexuality and ageing, 93 John E. Morley and Debbie T. Tolson 10 Physical fitness and exercise, 103 Maria A. Fiatarone Singh and John E. Morley 11 Health literacy and cultural sensitivity, 121 Nina Tumosa Part 2 Medicine and Prescribing in Old Age 12 Preventive geriatrics, 135 Gerald M. Mahon, Joseph H. Flaherty and Suzanne M. Mahon 13 Polypharmacy, 145 Oscar A. Cepeda and John E. Morley 14 Patient safety, 153 Susannah Long and Charles Vincent Section 1 Eating Disorders and Nutritional Health 15 Epidemiology of nutrition and ageing, 173 Wija A. van Staveren and Lisette C.P.G.M. de Groot 16 The anorexia of ageing, 185 Ian M. Chapman 17 Weight loss, 197 David R. Thomas 18 Dehydration, 209 David R. Thomas 19 Vitamins and minerals, 217 Seema Joshi and John E. Morley 20 Obesity, 237 Joan Khoo, Richard Y.T. Chen and Gary A. Wittert Section 2 Gastro Disorders 21 Changes in gastrointestinal motor and sensory function associated with ageing, 249 Christopher K. Rayner and Michael Horowitz 22 Gastrointestinal bleeding, 265 Syed H. Tariq 23 Liver and gall bladder, 275 Margaret-Mary G. Wilson 24 Sphincter function, 289 Syed H. Tariq 25 Constipation, 303 Charlene M. Prather 26 Management of diarrhoea, 313 Lenise A. Cummings-Vaughn 27 Diseases of the pancreas, 321 John S. Morris and John E. Morley Section 3 Haematological Disorders 28 Anaemia, 331 Anjali S. Kamat and David R. Thomas 29 Disorders of haemostasis, 343 Kingsley K. Hampton 30 Disseminated intravascular coagulation, 353 Kingsley K. Hampton 31 Anticoagulants, 357 Hamsaraj G.M. Shetty and Philip A. Routledge 32 Myelodysplasia, 363 Martha Wadleigh, David S. Rosenthal and Richard M. Stone 33 Management of myelodysplastic syndromes and acute leukaemia, 375 Heidi D. Klepin and Bayard L. Powell Section 4 Cardiovascular Diseases and Health 34 Epidemiology of heart disease, 389 Ahmed H. Abdelhafiz 35 Cardiac ageing and systemic disorders, 405 David J. Stott and Terence J. Quinn 36 Arrhythmias, 413 Abhay Bajpai and A. John Camm 37 Ischaemic heart disease, 437 Wilbert S. Aronow 38 Lipid management, 449 Adie Viljoen and Anthony S. Wierzbicki 39 Hypotension, 461 Suraj Alakkassery 40 Hypertension, 471 Anthony S. Wierzbicki and Adie Viljoen 41 Heart failure, 483 Michael W. Rich 42 Cardiac surgery, 499 Ulrich O. von Oppell and Adam Szafranek 43 Peripheral arterial disease, 517 Leocadio Rodryguez Manas, Marta Castro Rodryguez and Cristina Alonso Bouzon 44 Venous thromboembolism, 529 Gordon D.O. Lowe 45 Cardiac rehabilitation, 535 Niccolo Marchionni, Francesco Fattirolli, Francesco Orso, Marco Baccini, Lucio A. Rinaldi and Giulio Masotti Section 5 Respiratory Diseases 46 Epidemiology of respiratory infection, 551 Joseph M. Mylotte 47 Pneumonia, 555 Joel Belmin 48 Aspiration pneumonia, 565 Takashi Ohrui and Hiroyuki Arai 49 Interstitial lung disease and lung cancer, 573 Christopher Dyer 50 Chronic obstructive pulmonary disease and asthma, 579 Christopher Dyer 51 Pulmonary hypertension, 589 Dennis J. Shale 52 Pulmonary rehabilitation, 601 Peter Spiegler and Jonathan Ilowite Section 6 CNS Disorders 53 Neurological signs of ageing, 609 Andrew J. Larner 54 Sleep apnoea and sleep disorders, 617 Paul Montgomery and Lindsay Dianne Shepard 55 Headache, 629 Stephen D. Silberstein and William B. Young 56 Normal pressure hydrocephalus, 643 Dennis S. Oh and Peter McL. Black 57 Acute stroke care and management of carotid artery stenosis, 655 David Doig and Martin M. Brown 58 Stroke and stroke rehabilitation, 675 Lalit Kalra 59 Communication disorders and dysphagia, 691 Pamela M. Enderby 60 Acute and chronic subdural haematoma, 701 Eric Schmidt and Emmanuel Moyse 61 Epilepsy, 711 Pamela M. Crawford 62 Syncope and non-epileptic attacks, 721 Richard C. Roberts 63 Parkinson's disease, 731 Joel Belmin 64 Non-parkinsonian movement disorders, 739 Katie Kompoliti and Cynthia L. Comella 65 Diabetic neuropathy, 751 Aaron I. Vinik and Elsa S. Strotmeyer 66 Disorders of the neuromuscular junction, 769 Sivakumar Sathasivam and Andrew J. Larner 67 Muscle disorders, 779 David Hilton-Jones 68 Motor neurone disease, 793 Hardev S. Pall 69 Control of chronic pain, 809 Robert D. Helme and Benny Katz 70 Multiple sclerosis, 823 Florian P. Thomas Appendix Function assessment scales, i John E. Morley Index, xi A colour plate section is to be found in Volume 2, between pages 1414 and 1415 Contents of Volume 2 About the Editors, xiii List of Contributors, xv Preface to the Fourth Edition, xxiii Preface to the Fifth Edition, xxv Foreword, xxvii Section 7 Dementia and Cognitive Disorders 71 Delirium, 837 Joseph H. Flaherty 72 Memory clinics, 851 Antony Bayer 73 Alzheimer's disease, 865 James E. Galvin 74 Mild cognitive impairment, 881 Eric G. Tangalos and Ronald C. Petersen 75 Vascular dementia, 895 Marie-Laure Seux 76 Mental stimulation and dementia, 903 Joe Verghese 77 Exercise and dementia, 911 Yves Rolland 78 Drug development and Alzheimer s disease, 923 Julien Delrieu, Antoine Piau and Bruno Vellas 79 Other dementias, 943 Wee Shiong Lim 80 Treatment of behavioural disorders, 961 Ladislav Volicer 81 Geriatric psychiatry, 977 Abhilash K. Desai and George T. Grossberg 82 Organization of services in geriatric psychiatry, 991 Susan Mary Benbow and David Jolley 83 Depression in later life: aetiology, epidemiology, assessment, diagnosis and treatment, 1001 Natalie Sachs-Ericsson and Dan G. Blazer 84 The older patient with Down syndrome, 1017 John E. Morley Section 8 Special Senses 85 Disorders of the eye, 1025 Nina Tumosa 86 The ageing auditory system pathology and epidemiology of age-related hearing loss, 1033 Mathieu Marx and Olivier Deguine 87 Disorders of the vestibular system, 1047 Charlotte Agrup and Linda M. Luxon 88 Smell and taste, 1061 Richard L. Doty Section 9 Bone and Joint Health 89 Paget's disease of bone, 1075 Horace M. Perry III 90 Management of osteoporosis; its consequences: a major threat to quality of life, 1083 Roger M. Francis 91 Gait, balance and falls, 1091 Dulce M. Cruz-Oliver 92 Foot problems, 1111 Arthur E. Helfand and Donald F. Jessett 93 Hip fracture and orthogeriatrics, 1131 Christine Lafont 94 Diseases of the joints, 1145 Terry L. Moore Section 10 Endocrine and Metabolic Disorders 95 Endocrinology of ageing, 1155 John E. Morley and Kim J. Moon 96 Water and electrolyte balances in ageing, 1163 Stewart G. Albert 97 The pituitary gland, 1173 James F. Lamb and John E. Morley 98 Thyroid disorders, 1183 Ligia J. Dominguez, Mario Belvedere and Mario Barbagallo 99 Ovarian function and menopause, 1199 Nicola Pluchino, Tommaso Simoncini and Andrea R. Genazzani 100 Testicular function, 1211 Nazem Bassil 101 Diabetes mellitus, 1225 Alan J. Sinclair and Graydon S. Meneilly 102 New therapies for diabetes mellitus, 1241 George T. Griffing Section 11 Urogenital Disorders 103 Gynaecology and the older patient, 1261 Radha Indusekhar, Fidelma O'Mahony and P.M Shaughn O'Brien 104 The ageing bladder, 1271 James M. Cummings and Kimberly C. Berni 105 Prostate diseases, 1281 Clement Gaudin, Nicolas Doumerc, Loic Mourey, Stephane Gerard and Laurent Balardy 106 Urinary incontinence, 1299 Ramzi R. Hajjar 107 Geriatric nephrology, 1309 Carlos G. Musso and Dimitrios G. Oreopoulos Section 12 Cancer 108 Cancer and ageing, 1319 Tanya M. Wildes 109 Oncological emergencies, 1333 Chantal Bernard-Marty, Clement Gaudin, Stephane Gerard and Laurent Balardy 110 Breast cancer, 1345 Robert E. Mansel and Bedanta P. Baruah 111 Maintaining functional status, 1355 Miriam B. Rodin Section 13 Functional Disorders and Rehabilitation 112 Multidimensional geriatric assessment, 1377 Laurence Z. Rubenstein and Andreas E. Stuck 113 Frailty, 1387 John E. Morley 114 Rehabilitation, 1395 Michael Watts and Paul Finucane Section 14 Iatrogenic Infections 115 Tuberculosis, 1415 Shobita Rajagopalan and Thomas T. Yoshikawa 116 Valvular heart disease and infective endocarditis, 1425 Aneil Malhotra, Sam Dawkins and Bernard D. Prendergast 117 Infections of the central nervous system, 1447 Michael Blank and Allan R. Tunkel Section 15 Special Issues I Abuse and older people 118 Elder abuse: a UK perspective, 1467 Claudia Cooper and Gill Livingston 119 Good quality care: abuse, 1473 Jean-Pierre Aquino and Genevieve Ruault 120 Alcohol consumption and cognition, 1479 Luc Letenneur and Jean-Francois Dartigues 121 Drug misuse and the older person: a contradiction in terms?, 1483 Antoine Piau and Fatima Nourhashemi 122 The use and abuse of prescribed medicines, 1495 Abdi Sanati and Mohammed T. Abou-Saleh II Emerging themes 123 Transportation, driving and older adults, 1503 Desmond O'Neill and David Carr 124 Smart homes, 1513 Roger Orpwood III Dermatology 125 Skin disorders, 1525 Robert A. Norman and Jaffer Babaa 126 The prevention and management of pressure ulcers, 1531 David R. Thomas IV Surgical themes 127 Perioperative and postoperative medical assessment, 1545 Milta Oyola Little 128 Anaesthesia, 1557 Suzanne Crowe V Ageing themes and ethical issues 129 Health issues in the ageing female, 1569 Carolyn D. Philpot 130 Antiageing strategies, 1575 Ligia J. Dominguez and Mario Barbagallo 131 Ethics in geriatric medicine, 1589 Francois Blanchard 132 Participation of older people in clinical trials, 1595 Nicola Coley and Sandrine Andrieu 133 Restraints and immobility, 1607 Elizabeth A. Capezuti, Laura M. Wagner and Kathleen C. Reid 134 Centenarians, 1621 Thomas T. Perls VI End-of-life care 135 End-of-life and palliative care, 1631 Rachelle E. Bernacki, Ryan Westhoff and Miguel A. Paniagua 136 End-of-life care: special issues, 1641 Victoria J. Wheatley and Ilora G. Finlay Part 3 Global Healthcare Systems 137 Improving quality of care, 1653 Julie K. Gammack and Carolyn D. Philpot 138 Clinical audit of healthcare, 1673 Rhona Buckingham, Jonathan Potter and Adrian Wagg 139 Carers and the role of the family, 1687 Jo Moriarty 140 Nursing home care, 1697 David R. Thomas, Yves Rolland and John E. Morley 141 Geriatric occupational therapy: achieving quality in daily living, 1709 Karen F. Barney 142 Geriatric medicine education in Europe and the United States, 1719 Antonio Cherubini, Philippe Huber, Jean-Pierre Michel and Miguel A. Paniagua 143 Systems of healthcare: the United States, 1725 Julie K. Gammack 144 Systems of healthcare: Australia, 1735 Gideon A. Caplan 145 Systems of healthcare: the United Kingdom, 1741 Simon Conroy 146 Geriatric medicine in China, 1747 Leung-Wing Chu 147 Ageing in developing countries, 1761 Renato Maia Guimaraes 148 Geriatric medicine in the European Union: towards unification of diversity, 1765 Alfonso J. Cruz-Jentoft Appendix Function assessment scales, i John E. Morley Index, xi A colour plate section is to be found in Volume 2, between pages 1414 and 1415