Non-obstructive azoospermia (NOA) is characterized by the absence of sperm in the ejaculate due to a failure of the testes to produce sperm and is the cause of infertility in about 1% of adult men. This condition can result from various factors, including genetic abnormalities, hormonal imbalances, and environmental factors. Although NOA can make it difficult for men to conceive a child, there are treatment options available. These  include hormonal therapy, surgical procedures, and assisted reproductive techniques such as intracytoplasmic sperm injection (ICSI). The book begins with an introduction to NOA, including its definition, diagnosis, and epidemiology. The authors then provide a comprehensive discussion on the different aspects of NOA. Topics include  endocrine aberrations, the genetic spectrum of NOA, primary and secondary hypogonadism, fertility restoration, surgical approaches for sperm retrieval, and much more. It also explores the psychological and emotional impact of this condition on men and their partners. At the end, the book discusses the most recent international guidelines on NOA as well as what the future holds for NOA, such as experimental therapies, advancements in ART, and new research. Non-Obstructive Azoospermia: A Comprehensive Guide to Causes, Diagnosis, and Treatment provides a comprehensive understanding of NOA, including its causes, diagnosis, and treatment options. By sharing the latest research, clinical practices, and patient experiences, this book aims to provide a valuable resource for healthcare professionals, researchers, and patients dealing with non-obstructive azoospermia.