The Joint Royal Colleges Ambulance Liaison Committee Clinical Guidelines are the essential resource for paramedics. The guidelines are written specifically for the ambulance paramedic role, combining expert advice with practical guidance. They provide a comprehensive overview of the principle areas paramedics may encounter, and support them in providing excellent patient care. This 2025 edition has been updated with the latest evidence and developments in clinical practice. Key reviews have taken place on guidelines within the Resuscitation and Maternity sections, as well as updates to Medical guidelines such as Seizures in Adults and Children and Pain Management. Medicine guidelines have been removed, but are available on the iCPG and JRCALC Plus apps, where they are regularly updated to ensure that the most up-to-date guidance is available to clinicians. The JRCALC Clinical Guidelines 2025 now contains crucial guidance on topics, including: • Behavioural Disturbances • Clinical Considerations in Relation to Diversity and Equality • Conditions Requiring Specific Prehospital Clinical Management • Drowning • Overdose and poisoning