Protein-based Nanoparticles in Drug Delivery is a comprehensive book aimed at pharmaceutical scientists and researchers both in academia and corporate environments focused on nanotechnology drug delivery and pharmaceutical-related disciplines. The book covers the design and characterization of various protein nanoparticles, sheds light on the power of an endogenous substance as a drug delivery system, and highlights the possible future trends in the use of protein-based drug delivery. It covers in-depth novel applications of protein-based drug delivery from fundamental to most current use cases. The book comprises three parts. Part one is devoted to the foundations of protein-based drug delivery, including nanocarriers development, drug encapsulation, targetability, and in vivo properties. Part two explores the applications of protein-based nanoparticles in drug delivery, covering topics such as protein nanoparticles in cancer therapy, genetic material delivery, and nanocarriers based on milk protein, silk, and gliadin. Part three addresses recent advances and regulatory aspects of protein-based nanoparticles in drug delivery, including clinical translation, challenges, biological toxicity, and environmental hazards associated with protein-based nanoparticles. Protein-based Nanoparticles in Drug Delivery provides a complete journey of protein-based drug delivery, offers an in-depth understanding of the design and characterization of various protein nanoparticles, and highlights possible future trends in this field. Pharmaceutical scientists will benefit from the novel applications of protein-based nanoparticles drug delivery approaches in the biological field. Nanotechnologists, biologists, chemists, physicists, engineers, and clinicians will also benefit from the foundational content provided as a basis to support communication and tackle the multidisciplinary challenges associated with research in this exciting field.
Part I - Foundations of protein-based drug delivery
1. Fundamental of nanocarriers development: Drug encapsulation, targetability, stimuli-response and in vivo properties
2. History, introduction, properties, applications of protein-based drug delivery
3. Methods of preparation, characterization parameters and pharmaceutical application for protein-based nanoparticles
4. Design, development and drug delivery applications of self-assembling nanocarriers from engineered proteins
5. Mechanism of protein-nanoparticle interactions
Part II - Applications of protein-based nanoparticles in drug delivery
6. Protein nanoparticles in cancer therapy
7. Protein nanoparticles in cancer imaging
8. Protein-based nanotechnologies as cancer theranostics
9. Protein-based nanoparticles for the delivery of genetic materials
10. Gelatin based nanocarriers for drug delivery
11. Human serum albumin based nanocarriers for drug delivery
12. Bovine serum albumin based nanocarriers for drug delivery
13. Milk protein / casein based nanocarriers for drug delivery
14. Silk based nanocarriers for drug delivery
15. Zein based nanocarriers for drug delivery
16. Gliadin based nanocarriers for drug delivery
17. Lectin based nanocarriers for drug delivery
18. Legumin based nanocarriers for drug delivery
19. Elastin-Like Polypeptides (ELPs) based nanocarriers for drug delivery
20. Virus-Like Proteins (VLPs) based nanocarriers for drug delivery
Part III – Recent advances and regulatory aspects of protein-based nanoparticles in drug delivery
21. Recent advancement in co-delivery of proteins and small molecule drugs for targeted therapy
22. Recent updates in protein nanoparticle vaccine platforms
23. Recent advances in protein based nano delivery systems in overcoming the challenges associated with metastatic cancers
24. Clinical translation, challenges, biological toxicity and environmental hazards associated with protein-based nanoparticles
25. Conclusion and future prospective of protein-based nanoparticles
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