Biomechanics of the Heart: From Model to Patient provides readers with a comprehensive overview of the modelling and assessment of the heart’s biomechanics. It addresses topics such as the physiology of normal and diseased hearts, cardiovascular imaging, modelling of myocardial tissue in the passive and active states, as well as state-of-the-art approaches for patient specific modelling of the heart’s mechanical function. This is augmented by case studies and examples of the exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases. Readers are introduced to modelling of the heart’s anatomical and muscular structure, a review of imaging techniques to analyze the geometry, content and dynamics of the heart, as well as an in-depth look at the biomechanical properties of normal and diseased hearts. Chapters also cover modelling cardiac passive and contractile mechanics, biomechanical finite element simulations of the heart, patient-specific modeling of the heart and circulatory system, as well as the exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases.
Part I: The Normal and Diseased Heart
1. Anatomy, physiology, and hemodynamics of the healthy human heart
2. Heart pathologies affecting the myocardium
Part II: Imaging cardiac structures, strains, flow, and tissue properties
3. Echocardiography
4. Cardiac MRI: motion quantification
5. Cardiac MRI: DTI
6. Myocardial microstructure imaging
7. Pressure/volume measurements and hemodynamic measurements
8. Heart modeling combined with image simulation
Part III: Myocardial Tissue Modeling
9. Subcellular/molecular mechanics
10. Myocardial energetics
11. Passive myocardial properties and material laws
12. Myocardial poro-elastic models
13. Modeling myocardial scars and oedema
Part IV: Heart and Cardiovascular Modeling (Organ Level)
14. Cardia anatomy, shape modeling, cardiac atlases
15. Whole heart modeling coupled with cardiovascular system
16. Generic modeling of pathologies
Part V: Heart and Myocardial growth
17. Modeling myocardial growth and development
18. Tissue growth and engineering
Part VI: Translation of models to the clinic
19. Patient-specific cardiovascular modeling for diagnosis and prognosis
20. Patient-specific heart modeling and ML
21. 4-chamber heart modeling
22. Congenital heart modeling
23. Advanced therapies, surgical interventions
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