Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics.
1. Overview of mitochondria
2. Structural organization of mitochondria and mitochondrial genetics in different animal models
3. Mitophagy
4. Introduction to MAVS in different livestock species
5. Mitogenomics and metabolic disease
6. Mitogenomics and viral disease
7. Mitogenomics and bacterial disease
8. Mitogenomics and parasitic disease
9. Mitogenomics and fungal infestations
10. Mitogenomics and neurodegenerative disorder
11. Mitogenomics and cancer
12. Numtogenesis and its association to disease
13. Whole mitochondrial genome sequencing and its implication in diseases in animal models
14. Mitochondrial replacement therapy: Its prospects
15. Implication of gene editing in mitochondrial repair
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