ATP: Extracellular Communication in Health And Disease delivers a comprehensive discussion of extracellular ATP biology and its communication role in both homeostasis and pathologic states. It explores the function of ATP across the nervous, sensory, musculoskeletal, cutaneous cardiovascular, pulmonary, gastrointestinal, urinary, reproductive, exocrine, haematopoietic and immune systems. The book considers ATP in the context of various disease states, including cardiovascular, respiratory, psychiatric, inflammatory and neurodegenerative disorders, as well as pain and sensory disorders, infectious diseases, and cancer. ATP in humans is explored alongside other species, including rodents, fish, and plants. This is the latest volume in the “Molecular Mediators in Health and Disease” series. With contributions from specialists across pharmacology, physiology, biophysics, biochemistry, immunology, anatomy, molecular biology, therapeutics, and other critical fields, this volume provides a broad and detailed overview of ATP which will be helpful to researchers working in these areas and beyond.
Part I - Introduction to extracellular ATP
1. History of ATP and purinergic signalling
2. Extracellular ATP in normal biology
Part II – Molecular biology of extracellular ATP signalling
3. Extracellular ATP
4. P2X receptors
5. P2Y receptors
6. Regulation of extracellular ATP by ectonucleotidases
Part III – Extracellular ATP in organ function
7. Extracellular ATP and the oral cavity
8. Extracellular ATP and blood vessels
9. Extracellular ATP and the heart and carotid body
10. Extracellular ATP and the lung
11. Extracellular ATP and metabolism
12. Extracellular ATP and the gastrointestinal tract
13. Extracellular ATP and the liver
14. Extracellular ATP and the pancreas
15. Extracellular ATP and the kidneys
16. Extracellular ATP and the bladder
17. Extracellular ATP and the central nervous system
18. Extracellular ATP and the peripheral nervous system
19. Extracellular ATP and the eye
20. Extracellular ATP and the ear
21. Extracellular ATP and the reproductive organs
22. Extracellular ATP and the skin
23. Extracellular ATP and the bone
24. Extracellular ATP and skeletal muscle
25. Extracellular ATP and haematopoietic stem and progenitor cells
26. Extracellular ATP and platelets
27. Extracellular ATP and red blood cells
28. Extracellular ATP and innate immune cells
29. Extracellular ATP and adaptive immune cells
Part IV - Pharmacology of extracellular ATP signalling
30. Extracellular ATP and P2X receptors)
31. Extracellular ATP and P2Y receptors
Part V - Extracellular ATP in non-mammalian biology
32. Extracellular ATP in fish
33. Extracellular ATP in primitive species
34. Extracellular ATP in plants
Part VI - Extracellular ATP in Disease
35. Extracellular ATP in aged-related disorders
36. Extracellular ATP in cardiovascular disorders
37. Extracellular ATP in respiratory disorders
38. Extracellular ATP in gastrointestinal disorders
40. 39. Extracellular ATP in brain diseases
41. Extracellular ATP in neurodegenerative disorders
42. Extracellular ATP in psychiatric disorders
43. Extracellular ATP in pain
44. Extracellular ATP in other sensory disorders
45. Extracellular ATP in infectious disease
46. Extracellular ATP in inflammatory disorders
47. Extracellular ATP in cancer
48. Extracellular ATP and future directions
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