This book presents advanced concepts of computer-aided design, and computer-aided manufacture, through modelling and computer numerical control, coupled with simulation of production systems. It dwells on the subtle and key features such as the applications and effective use of dynamic blocks in modelling, subtractive and additive layer manufacturing, flexible manufacturing systems as well as automation and robotics. The text: Discusses principles of computer-aided design in a comprehensive manner and applications of the AutoCAD interface programming language. Covers aspects of product development and design, together with accompanying principles of design for manufacture and assembly. Explains the integrated approach to design and manufacture, enhanced by modelling, simulation, and analysis software, with capabilities for electronic transfer and interchange between the software packages. Presents process planning and part programming with MasterCAM, generating toolpaths, and selecting machine tools for subtractive manufacturing and step-by-step worked examples to enhance understanding of the principles and concepts of engineering design and manufacture. Explores sequential control and logical sequencing, configuration of industrial robots, and challenges in programming robots. The integrated nature of this book and the examples therein, are intended for senior undergraduates, graduate students, academic researchers, and practising engineers in various fields of engineering, such as, but not limited to; aeronautical, civil, electrical, industrial, manufacturing, mechanical, mechatronics, and production engineering.