Radiation Biology explores a range of molecular processes that lead to specific responses to radiation. Topics covered include radiation-Induced DNA damages and repair processes, molecular pathways of cell death, molecular signaling in irradiated cells, and cell response to radiation. The book also explores cell cycle control, immunotherapy and radiation effects on the immune system, tumor microenvironment and metabolism, and epigenetics. Later chapters consider multiple topics in cancer biology, such as chemotherapeutic agents, radiation carcinogenesis, hallmarks of cancer, as well as responses to radiation at the tissue, organ and whole-body scale. This book provides an up to date and detailed overview of the latest advances in the field of radiation biology and its impact at a molecular scale, acting as an ideal reference for researchers working in molecular biology, oncology, and related fields.
1. Basics of Radiation Physics and Chemistry
2. Radiation-Induced DNA Damages and DNA Repair Processes
3. Molecular Pathways of Cell Death
4. Radiotherapy and Immune Checkpoint Blockade
5. Molecular Signaling in Irradiated Cells
6. Cell-Survival Curves
7. Impact of Cell Cycle Phase, Dose Rate and Kinetic Factors on Radiation Responses
8. The Role of Oxygen in Irradiated Cells
9. The Use of Hypofractionation, Hyperfractionation and Accelerated Treatment in Radiotherapy
10. Angiogenesis, Microenvironment and Metastasis and Radiation Responses
11. Linear Energy Transfer and Relative Biological Effectiveness
12. Radiation Sensitizers
13. Radioprotectors and Radiomitigators
14. Particle Beam Radiotherapy
15. Predictive Assays in Radiotherapy
16. Interaction of Heat and Radiation
17. Classical and Targeted Chemotherapeutic Agents and Interaction with Radiation
18. Radiation Carcinogenesis
19. Hereditary Effects of Radiation
20. In Utero Radiation Effects
21. Radiation Protection Guidelines
22. Normal Tissue and Organ Radiation Responses
23. Whole-Body Radiation Effects
24. Topics in Cancer Biology Relevant to Radiation Oncology
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