This book provides an overview of antimicrobial resistance (AMR), including its underlying causes, mechanisms, global ramifications, and the potential of probiotics as a viable approach in combating AMR. It explores the potential of probiotics to counteract resistance by competing with pathogenic bacteria, modulating the immune system, and producing antimicrobial substances. It also examines the applications of probiotics in biofilm-related infections, respiratory health, urinary tract infections, and oral health. Additionally, the book covers important considerations such as safety, regulatory frameworks, challenges, and risks associated with probiotics in antimicrobial resistance. It provides insights into the development of novel approaches, including engineering probiotics for enhanced antimicrobial activity and exploring synergistic approaches by combining probiotics with traditional antibiotics. Towards the end, the book explores future directions and potential applications of probiotics, including their role in neonatal care and personalized probiotic interventions. This book is primarily intended for healthcare professionals, researchers, and individuals working in the fields of microbiology, infectious diseases, and public health. Key feature 1) Discusses the mechanisms, impacts, and global concerns associated with antimicrobial resistance 2) Highlights the various methods utilized by probiotics, to effectively counter resistant pathogens 3) Explores the potential of probiotics in enhancing human health and combating antimicrobial resistance 4) Presents novel approaches, such as engineering probiotics for enhanced antimicrobial activity 5) Focuses on personalized probiotics and their role in bridging the gap between antimicrobial resistance and nutritional precision 6) Examines safety considerations and regulatory frameworks for probiotics in the context of antimicrobial resistance