Essentials of Stem Cell Biology, Fourth Edition is designed for the growing community of scientists, researchers, practitioners, and students embracing the latest advancements in stem cells. This comprehensive book, a collaboration of 7 editors and over 200 pioneering scholars and scientists, provides a thorough understanding of adult and embryonic stem cells. It combines fundamental concepts with cutting-edge research in specific organ systems, ensuring a robust foundation for anyone entering the field. Beyond the basics, the book delves into early development and the differentiation of ectoderm, mesoderm, and endoderm.
It covers methods, applications to human diseases, regulation, ethics, and patient perspectives, leaving no stone unturned in the stem cell domain.
PART ONE: INTRODUCTION TO STEM CELLS
1. Why Stem Cell Research? Advances in the Field
2. ‘Stemness’: Definitions, Criteria, and Standards
3. Pluripotent Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges
4. Embryonic Stem Cells in Perspective
5. The Development of Epithelial Stem Cell Concepts
PART TWO: BASIC BIOLOGY/MECHANISMS
6. Stem Cell Niches
7. Mechanisms of Stem Cell Self-Renewal
8. Cell Cycle Regulators in Stem Cells
9. How Cells Change Their Phenotype
PART THREE: TISSUE AND ORGAN DEVELOPMENT
10. Differentiation in Early Development
11. Stem Cells Derived from Amniotic Fluid
12. Stem and Progenitor Cells Isolated from Cord Blood
13. The Nervous System
14. Sensory Epithelium of the Eye and Ear
15. Epithelial Skin Stem Cells
16. Hematopoietic Stem Cells
17. Peripheral Blood Stem Cells
18. Multipotent Adult Progenitor Cells
19. Mesenchymal Stem Cells
20. Skeletal Muscle Stem Cells
21. Stem Cells and the Regenerating Heart
22. Cell Lineages and Stem Cells in the Embryonic Kidney
23. Adult Liver Stem Cells
24. Pancreatic Stem Cells
25. Stem Cells in the Gastrointestinal Tract
PART FOUR: METHODS
26. Induced Pluripotent Stem Cells
27. Embryonic Stem Cells: Derivation and Properties
28. Isolation and Maintenance of Murine Embryonic Stem Cells
29. Approaches for Derivation and Maintenance of Human Embryonic Stem Cells: Detailed Procedures and Alternatives
30. Derivation and Differentiation of Human Embryonic Germ Cells
PART FIVE: APPLICATIONS
32. Neural Stem Cells – Therapeutic Applications in Neurodegenerative Diseases
33. Adult Progenitor Cells as a Potential Treatment for Diabetes
34. Burns and Skin Ulcers
35. Stem Cells and Heart Disease
36. Stem Cells for the Treatment of Muscular Dystrophy
37. Cell Therapy for Liver Disease: From Hepatocytes to Stem Cells
38. Orthopedic Applications of Stem Cells
39. Embryonic Stem Cells in Tissue Engineering
PART SIX: REGULATION AND ETHICS
40. Ethical Considerations
41. Overview of the FDA Regulatory Process
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