Fundamentals of Redox Biology provides a complete introduction to the cellular redox systems, exploring their regulation, physiological role and significance to human diseases. The book begins with a historical overview before exploring the fundamental characteristics and functions of free radicals and reactive oxygen species. Their role in redox signaling and epigenetic regulation are covered, as well as the impact of antioxidants on redox homeostasis. Additionally, the book explores how ROS can lead to oxidative stress and various disease states, including cancer, cardiovascular and neurological disorders, while also considering the role of mitochondrial ROS in the immune response against various infections.
Biology of cellular redox systems has now become an integral part of many disciplines across the life sciences. This book provides a foundational overview of the topic which will be useful to those in the field of biochemistry, cell biology, molecular biology, immunology, and related areas.
Section A: General topics
1. Free radicals and reactive species in human health and diseases: a historical perspective
2. Biochemistry of free radicals and reactive oxygen species
3. Tools and techniques for the detection and estimation of cellular ROS and other reactive species
4. Redox signaling
5. Role of ROS in genetic and epigenetic regulations
6. Cellular compartmentalization and its importance in the physiological functions of ROS
7. Antioxidants and their physiological roles in redox homeostasis
Section B: Specialized topics
8. Role of ROS in metabolism: the cancer cell paradigm
9. ROS and cardiovascular and neurological disorders
10. ROS, the immune response, and its evasion by the pathogens
11. Iron/copper homeostasis, ROS and ferroptosis
12. Role of cellular redox in organismal biology: lessons from yeast, C elegans, Zebrafish, and Drosophila
13. Role of ROS in plant development and stress responses
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