Lysosomal Pathophysiology of Parkinson’s Disease delves into the genetic and genomic revelations that have transformed our understanding of Parkinson’s Disease at the molecular level. The book highlights the critical role of the autophagy-lysosome pathway in the disease's pathogenic processes, drawing a comprehensive timeline of disease onset and progression. It offers a detailed examination of how disruptions in this pathway contribute to the hallmarks of Parkinson’s Disease, providing invaluable insights for researchers and clinicians alike. Subsequent chapters extend these insights by comparing Parkinson’s Disease to other neurodegenerative disorders such as Alzheimer’s Disease and Frontotemporal Dementia.
By exploring protein pathology and synaptic alterations, the book underscores the broader implications of autophagy-lysosome dysfunction. Additionally, it discusses how the molecular perspectives gleaned from Parkinson’s Disease can inform our understanding of these other conditions, presenting a unified approach to studying neurodegeneration.
Part 1: A molecular reappraisal of Parkinson’s disease
1. Clinical and neuropathological presentation of Parkinson’s disease
2. The genetic revolution: towards an etiology-based view
3. Neuronal processes involved in etiology
4. Non-neuronal mechanisms of disease
5. The autophagy-lysosome pathway as convergence point of pathogenesis
Part 2: Autophagy-Lysosome function in Parkinson’s pathophysiology
6. Molecular biology of the autophagy pathway
7. The functional roles of lysosomes
8. Physiology of lysosomes in the critical electrophysiological function of neurons
9. Lysosomes in Parkinson’s disease neuropathology
10. Lysosomal dysfunction in Parkinson’s disease etiology
Part 3: Therapeutic options targeting lysosome biology
11. Current therapies for PD
12. Targeting options in lysosome biology
13. Autophagy-Lysosome-based therapies in neurological disorders
14. An update on clinical trials for autophagy-lysosome therapies in Parkinson’s disease
15. Prospective targeting strategies and drug development
Part 4: Neurobiological commonalities with other neurodegenerative proteinopathies
16. The autophagy-lysosome pathway and overlaps with Alzheimer-like pathologies
17. The autophagy-lysosome pathway in other neurodegenerative diseases
18. Synaptic dysfunction in neurodegeneration
19. Towards a common pathophysiology scenario in neurodegenerative diseases?
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