Parkinson’s Disease is a complex disease that affects millions of patients worldwide. Lysosomal pathophysiology has become an emerging key to better understanding the progression of Parkinson’s Disease. Lysosomal Pathophysiology of Parkinson’s Disease introduces how genetic and genomic insights shape the molecular view on Parkinson’s Disease. Specifically, this book presents data on the involvement of the autophagy-lysosome pathway in pathogenic processes. This book draws a timeline of disease onset and progression by examining the impact of autophagy-lysosome function to include other mechanisms and how to link these stages using the molecular lens. In addition, chapters will compare this example in Parkinson’s disease to other neurodegenerative diseases characterized by protein pathology and synaptic alterations, such as Alzheimer’s disease and Frontotemporal Dementia.
Part 1: A molecular reappraisal of Parkinson’s disease
1. Clinical and neuropathological presentation of Parkinson’s disease
2. The genetic revolution: towards an etiology-based view
3. Neuronal processes involved in etiology
4. Non-neuronal mechanisms of disease
5. The autophagy-lysosome pathway as convergence point of pathogenesis
Part 2: Autophagy-Lysosome function in Parkinson’s pathophysiology
6. Molecular biology of the autophagy pathway
7. The functional roles of lysosomes
8. Physiology of lysosomes in the critical electrophysiological function of neurons
9. Lysosomes in Parkinson’s disease neuropathology
10. Lysosomal dysfunction in Parkinson’s disease etiology
Part 3: Therapeutic options targeting lysosome biology
11. Current therapies for PD
12. Targeting options in lysosome biology
13. Autophagy-Lysosome-based therapies in neurological disorders
14. An update on clinical trials for autophagy-lysosome therapies in Parkinson’s disease
15. Prospective targeting strategies and drug development
Part 4: Neurobiological commonalities with other neurodegenerative proteinopathies
16. The autophagy-lysosome pathway and overlaps with Alzheimer-like pathologies
17. The autophagy-lysosome pathway in other neurodegenerative diseases
18. Synaptic dysfunction in neurodegeneration
19. Towards a common pathophysiology scenario in neurodegenerative diseases?
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