This book draws on the authors’ industry and academic expertise to explain the theory and practice of district cooling systems (DCS). The in-depth exploration of the design and development of DCS presents detailed best practices for their optimization in both development and operation phases. Readers will gain in-depth practical knowledge on all areas and considerations related to DCS technology best practice, including current practical research areas and future potential research areas. This book addresses five areas related to DCSs: the fundamentals of DCS technology; design optimization for development purposes; real-time optimization for daily operations; techno-commercial decision-making framework; and industry best practice. This information is presented through analyses of technological progress to date, case studies of current operations, and in-depth discussions of the theoretical bases and commercial, technical, and environmental benefits. Through this book, readers can recognize and apply best practices for the design, development, and operation of an optimal DCS design based on multiple factors including financial analysis, energy efficiency considerations, and practical operation issues. This will enable them to contribute to national and international sustainable development goals regarding sustainable cities and climate action. As this book provides both industry know-how and future research directions related to DCS, it is invaluable for DCS industry professionals and advanced undergraduate and postgraduate engineering students who aim to enter this industry and develop leading, highly efficient DCS systems. Overall, it is a vital resource for anyone involved in the planning, execution, and management of DCS projects.