In this issue of Immunology and Allergy Clinics, guest editors Drs. Cullen M. Dutmer and Jessica Galant-Swafford bring their considerable expertise to the topic of Immune Deficiency. This issue is designed to enhance readers’ understanding of molecular diagnostic approaches for inborn errors of immunity and build a framework for interrogating gene sequencing results; help clinicians recognize the prevalence and importance of non-infectious complications of inborn errors of immunity, consider therapeutic interventions that are tailored to the molecular diagnosis, and learn to identify approaches to hasten time to diagnosis of inborn errors of immunity; and review the role of immunoglobulin therapy in managing disease and revisit how vaccinations can aid in probing humoral immunity integrity. Contains 12 relevant, practice-oriented topics defining the evolving role of the clinical immunologist; interpreting gene sequencing results; biomarkers of immune dysregulation and what they tell us; leveraging the expanding landscape of immunosuppressive and immunomodulatory agents to improve management strategies for primary immune regulatory disorders; non-infectious complications of chronic granulomatous disease; and more Provides in-depth clinical reviews on immune deficiency, offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews