This open-access book explores the growing role of palliative care in the Middle East, reflecting a global shift toward recognizing it as essential to public health and a fundamental right for patients with life-threatening illnesses. The World Health Organization (WHO) defines palliative care as a holistic approach addressing physical, emotional, and spiritual needs, extending beyond treatment to relieve suffering and improve quality of life. Delivered in hospitals, clinics, and homes, it engages families and communities through a multidisciplinary framework.  Each chapter highlights the dedication of healthcare professionals driving palliative care across the region, examining the challenges and successes they face. Country-specific sections showcase diverse models—hospital-based care, community programs, and home-based services—with home care emerging as an efficient and resource-friendly option. However, the book also addresses significant obstacles, including limited training for healthcare providers, gaps in pain management, restricted drug access, and inadequate communication skills and research. These challenges hinder the seamless integration of palliative care into comprehensive cancer care. The authors, distinguished leaders in their fields, offer insights into innovative programs and the path forward. The editor provides a framework that emphasizes the role of cultural context, settings, and resource availability in shaping the future of palliative care. This book serves both as a roadmap for the anticipated evolution of palliative care and as a tribute to the pioneers transforming it into a key element of cancer care in the Middle East. It stands as a valuable resource, reflecting the vision, dedication, and commitment of those working to provide compassionate, individualized care to patients with life-limiting illnesses.