Fundamentals of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.
Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain.
Section I An overview about Organoids
1. What are organoids?
2. Past, Present and Future scenario of organoids
Section II Neurological diseases
3. A brief introduction about Neurodevelopmental disorders
4. An overview of Neurodegenerative diseases
Section III Brain organoids for Neurodevelopmental disorders
5. Use of brain organoids for Autism
6. Role of brain organoids in Rett Syndrome
7. Role of brain organoids in Bipolar disorder
Section IV Brain organoids for Neurodegenerative diseases
8. Use of brain organoids for Parkinson’s disease (PD)
9. Role of brain organoids in Alzheimer’s disease (AD)
10. Application of brain organoids in Huntington’s disease (HD)
Section V Methods involved in organoids development
11. How HiPSCs are derived into organoids
12. Elements required for organoid generation
13. Days involved in organoid generation
14. Challenges while constructing organoids
Section VI Ongoing Clinical trials
15. Ongoing clinical trials on use of Brain organoids for neurodevelopmental disorders
16. Ongoing clinical trials on use of Brain organoids for neurodegenerative diseases
Section VII – Application and advancement of Brain organoids
17. Brain organoids – A promising disease model
18. Existing drug targeting using Brain organoids
19. New drug research by brain organoids
Section VII - Ethical consideration while conducting organoids research
Section IX - Future Direction and Conclusion
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