Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides an overview of these approaches and includes dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) MRI, magnetic resonance spectroscopy (MRS), resting state functional MRI (rsfMRI), microscopic diffusion imaging, and quantitative susceptibility mapping (QSM). Chapters then follow that present the application of these methods to Alzheimer’s Disease and vascular dementia, small vessel disease, Parkinson’s Disease, Lewy body dementia, Huntington’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.
Advanced MR Techniques for Neurodegenerative Diseases is a comprehensive resource on the latest advanced MR techniques and their application to neurodegenerative diseases, suitable for MR engineers and physicists as well as clinicians and neuroscientists who use MR techniques for diagnosis and research.
1: Introduction
Part 2: Basics of the relevant MRI technology (Acquisition, analysis and interpretation for neurodegenerative diseases)
2.1 Perfusion
2.1.1 Arterial Spin Labelling
2.1.2 Dynamic Contrast Enhanced MRI
2.1.3 Dynamic Susceptibility MRI
2.2 Flow (MRA, CSF, large vessel
2.3 Chemical Exchange Saturation Transfer and Magnetization Transfer Contrast–
2.4 Magnetic Resonance Spectroscopy
2.5 Resting State fMRI
2.6 Microscopic Diffusion Imaging
2.7 Susceptibility Weighted imaging and Quantitative Susceptibility Mapping
Part 3: Imaging the glymphatic system
3.1 Glymphatic system
3.2 DCE MRI of glymphatic system
3.3 CSF imaging
3.4
Part 4: Neurodegenerative diseases and neurovascular pathology - current state-of-art in MRI
4.1 Alzheimer’s disease -
4.1.1 The disease
4.1.2 Imaging animal models
4.1.3 Human imaging state of the art
4.2 Vascular dementia and cerebral small vessel
4.2.1 The disease
4.2.2 Imaging animal models
4.2.3 Human imaging state of the art
4.3 Parkinson’s and Lewy body dementia
4.3.1 The disease
4.3.2 Imaging animal models
4.3.3 Human imaging state of the art
4.4 Huntington’s disease
4.4.1 The disease
4.4.2 Imaging animal models
4.4.3 Human imaging state of the art
4.4.4
4.5 Amyotrophic Lateral Sclerosis
4.5.1 The disease
4.5.2 Imaging animal models
4.5.3 Human imaging state of the art
4.6 Multiple Sclerosis
4.6.1 The disease
4.6.2 Imaging animal models
4.6.3 Human imaging state of the art
Part 5: Future research challenges and directions - Editors
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