During the last years, there is an increase of field knowledge on a number of comorbidities and extra-articular manifestations (EAMs) associated with inflammatory arthritis. Many adults suffering from inflammatory arthritis also have other chronic conditions, so early detection is key to a patient’s quality of life and survivability outcomes. Comorbidities and Extra-articular Manifestations in Inflammatory Arthritis, the 18th volume in Elsevier’s Handbook for Systemic Autoimmune Diseases series, provides a comprehensive review of the latest research on various comorbidities and EAMs associated with inflammatory arthritis. The book chapters review comorbidities and extra-articular manifestations in early and late disease stages, mechanisms involved in comorbidities development, as well as the impact of new treatment strategies specific to inflammatory arthritis and cardiovascular disease, metabolic syndrome, metabolic bone, infection, neoplasia, respiratory, gastrointestinal, kidney, mental health disease, and neurological disease. This book serves as an ideal reference for researchers and clinicians focused on inflammatory arthritis and related diseases.