Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part Two, Volume Three covers wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examining their relationship with aging with an aim to target deteriorating redox signaling cascades and highlight promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing helps adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress.
However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity. This also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades.
1. Redox state of aging skin: A double-edged sword in wound healing
Qian Chen, Alex Sophabmixay, Thomas Albertson, Gabby Ghasb, Anna Terzian, Lloyd Yan, Lindon Young and Robert Barsotti
2. Redox signaling in pressure ulcers within older population: Role of the of antioxidants in their prevention and management
Catalina Rojas-Solé, Víctor Pinilla-González, José Lillo-Moya and Ramón Rodrigo
3. Redox signaling in intestinal mucosal wound healing
Pavel Marković and Jan Homolak
4. Gastrointestinal system senility, postsurgical wound healing, and redox signaling pathways
Anıl Orhan and Süleyman Demiryas
5. Redox signaling in age-related vascular disease and wound healing
Tamer Cebe, Fatih Kızılyel and Bülend Ketenci
6. Redox signaling in age-related ocular diseases and healing
Ahmad Kunbaz
7. ROS-mediated redox signaling in diabetic wound healing
Saeideh Momtaz and Mohammad Abdollahi
8. Nanotherapeutic approach for diabetic wound healing: Cross-talk between redox molecules
Muhammad Asim, Saadiya Zia, Haroon Ur Rashid, Abdul Nasir and Fatma Hussain
9. Cerium oxide-based redox active antioxidant and anti-inflammatory biomaterial for wound healing applications
Ankitha Suresh, Meghna Shetty and Bhisham Narayan Singh
10. The redox signaling of ozone in wound repair in the elderly. Perspectives for a thorough review about oxygen-ozone adjunct therapy in traumatic and post-surgical wounds
Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Sergio Pandolfi, Giovanni Ricevuti, Francesco Vaiano, Marianna Chierchia and Luigi Valdenassi
11. Contemporary redox-related therapeutic approach to burn wounds in the elderly
Mehmet Kaan Akgün, Sara Koçi, Mehmet Can Atayik and Ömer Cennet
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