Saliva as an alternate diagnostic fluid to blood is currently the focus of much attention worldwide as the horizons of saliva-diagnostics have expanded owing to advances in biomedical engineering technologies and biomarker validations. This book provides clinicians, academicians, students and researchers with the current advances in the field, enabling them to consider saliva-diagnostics as a viable alternative to blood-diagnostics and catalyze further advancements in the field. The book undertakes a critical review of the existing data on saliva biomolecules, the validation process for potential biomarkers, current areas of applications of saliva-diagnostics in systemic diseases or conditions, and technologies that aid these processes.