Current book will deal with wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging aim to target deteriorating redox signaling cascades, and will also focus on promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing will help adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress. However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity; it also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades. Redox-dependent second messengers are generated in subcellular locations according to specific rules and regulations. Their appearance depends on cellular needs in response to external and internal stimuli variations. A good understanding of the wound healing cascades, which deteriorate especially in advancing ages, is critical in developing the most appropriate approach. To understand the redox signaling mechanisms and healing cascades in wound healing, to pioneer new pharmacoactive drugs that can be developed based on these mechanisms, to reveal the deteriorating dynamics in the elderly patient group, and to propose new treatment methods suitable for the advanced age group.
1. Redox signaling in regenerative medicine: Mechanisms and therapeutic implications
Ali mohammad Sharifi and Tunku Kamarul
2. Age-related aspects of redox signaling cascades of wound healing
Arttatrana Pal, Golden Kumari and Monalisha Padhiary
3. Role of Nrf2 signaling in wound healing
Volodymyr I. Lushchak, Oleh Lushchak and Tetiana Dmytriv
4. Impact of senescence in impaired wound healing
Gabriel Méndez, Catalina Rojas-Solé, José Lillo-Moya and Ramón Rodrigo
5. Role of immunosenescence in impaired wound healing with age
Jan O. Nehlin, Juliette Tavenier, Line Jee Hartmann Rasmussen, Izzet Altintas and Ove Andersen
6. Targeting redox signaling pathway through integration of caloric restriction and wound healing process for enhanced repair
Abhishek Kumar Singh, Prachi Agarwal and Shweta Verma
7. CoQ10, more than an antioxidant in skin health and wound healing promotion
Guillermo López-Lluch Sr.
8. Redox state of aging skin: a double edge sword in wound healing
Qian Chen
9. Redox signaling in pressure ulcers within older population: Role of the of antioxidants in their prevention and management
Catalina Rojas-Solé, José Lillo-Moya, Víctor Pinilla-González and Ramón Rodrigo
10. Redox signaling in intestinal mucosal wound healing
Jan Homolak
11. Postsurgical wound healing and redox signaling pathways in gastrointestinal system
Anil Orhan
12. Role of redox signaling on wound healing caused by vascular pathologies with aging
Tamer Cebe, Bülend Ketenci and Fatih Kizilyel
13. Redox signaling and free radical mediated pathways in ocular diseases and tissue repair: Insights into the role of oxidative stress and redox signaling in retinal healing
Ahmad Kunbaz and Ahmad Alfaar
14. ROS-mediated redox signaling in diabetic wound healing
Mohammad Abdollahi
15. Nanotherapeutic approach for diabetic wound healing: Cross-talk between redox molecules
Fatma Hussain, Muhammad Asim, Saadiya Zia, Haroon Ur Rashid and Abdul Nasir
16. Cerium oxide based redox active antioxidant and anti-inflammatory biomaterial for wound healing applications.
Bihisham Narayan Singh
17. The redox signaling of ozone in wound repair in the elderly. Perspectives for a thorough review about oxygen-ozone adjunct therapy in traumatic and post-surgical wounds
Salvatore Chirumbolo
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