In this issue of Dental Clinics, guest editor Dr. Davis Thomas brings his considerable expertise to the topic of Systemic Factors Affecting Prognosis in Dentistry. Many health conditions and diseases can affect oral health, either systemically or due to physical inability to maintain appropriate oral hygiene. Conditions such as chronic pain, stress, or infections present a number of symptoms that may provide challenges to the dentist. This issue takes a holistic approach to treatment planning for systemic factors, with articles on implants, periodontal therapy, medications, genetics, orthodontics, and psychological issues. Contains 15 relevant, practice-oriented topics including systemic factors affecting prognosis of dental implants; COVID-19 and other emerging infections; genetics affecting prognosis of dental treatments; systemic factors affecting prognosis of pain management in dentistry; medications affecting treatment outcomes in dentistry; and more. Provides in-depth clinical reviews on systemic factors affecting prognosis in dentistry, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.