This book presents a comprehensive theory of human psycho-bio-physical relations and consequent routes through disruptions, changes, and harmonic equilibria, with applications in clinical psychology, social sciences and human interfaces. It clarifies how synchronizations generate complex and mixed states, and evolve into quantum dynamics, using a quantum relational mechanics perspective. Contemporary research following this approach are discussed thoroughly, with the aim of showing readers that chimera states are defining a more realistic picture of the hybrid dynamics involving semiotic cognition and biophysics. Flux: The Complexity of Changing Minds will provide a brand-new framework in clinical and social psychology, into which the second part of the book will delve with field examples and a toolbox for further implementations. It will also highlight new approaches to driving chimera couplings through phase transitions towards new self-organized, harmonic states.