In this issue of Oral and Maxillofacial Surgery Clinics, guest editor Dr. Seenu Susarla brings his considerable expertise to the topic of Pediatric Craniomaxillofacial Pathology. Top experts in the field discuss non-trauma management of craniomaxillofacial conditions, including soft tissue lesions, cysts and tumors, odontogenic infections, vascular anomalies, and head and neck malignancies. The issue begins with an important article on “A Conceptual Framework for the Differential Diagnosis of Pediatric Craniomaxillofacial Lesions,” which sets the stage for the subsequent articles. Contains 15 relevant, practice-oriented topics including pediatric temporomandibular joint pathology; pediatric orbital and skull base pathology; head and neck malignancies in children; conceptual principles in pediatric facial reconstruction; facial nerve pathology in children; and more. Provides in-depth clinical reviews on pediatric craniomaxillofacial pathology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.