The PyPSA Handbook: Integrated Power System Analysis and Renewable Energy Modeling’ is a unique guide to the landmark open-source program for modelling complex modern energy systems and their challenges. Beginning with fundamental concepts of the program and energy systems analysis, this book clearly outlines theoretical background and provides a firm foundation in PyPSA methodology. It moves steadily towards complex system modelling and analysis suitable even for the experienced user, including renewable integration, energy storage challenges, grid expansion planning, stability issues, and future developments. Including layered examples and exercises appropriate for both foundational and advanced practitioners, The PyPSA Handbook is an indispensable new resource for students, academics, and professionals working on energy systems.