Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region.
Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.
Section I: Basic human genetics and genomics
1. Population origin and variation of the South Asian peoples
2. Introduction to genomic and molecular biology
3. Microbial and Pathogenomics with reference to tropical infections
4. Pharmacogenetics and Pharmacogenomics including traditional/ indigenous herbal medicines
5. South Asia genomic heterogeneity in transplantation medicine
6. Genome databases and digital genomic healthcare
Section II: Hereditary disorders of the South Asian subcontinent
7. Epidemiology of inherited disorders of India and regional nations
8. Heterogeneity of hereditary diseases in South Asia
9. Metabolic and mitochondrial diseases
10. Haemoglobinopathies and related inherited blood diseases
11. Neurogenetics/ Neuro-psychiatric diseases
12. Inherited cardiovascular diseases
13. Inherited eye diseases in South Asia
14. Inherited immune deficiency disorders
15. Familial and Inherited cancer
16. Rare genetic diseases
Section III: Genomics of Infectious diseases
17. Malaria genomics and applications
18. Mycobacterial diseases genomics and Tuberculosis Including Leprosy
19. Leishmaniasis- the paradigm of tropical infectious disease
20. Viral diseases- HIV; Dengue; Chikangunia; Covid and others
21. Anti-microbial therapy- resistance; response; adverse drug reactions
22. Next generation drugs and vaccines
Section IV: Environmental and Life style diseases
23. Complex genetic and genomic diseases in South Asia
24. Diabetes and related glycemic diseases
25. Coronary artery disease and Hypertension
26. Respiratory diseases- Bronchial asthma and High altitude living
27. Inflammatory/ Auto-immune diseases
28. Gastro-intestinal diseases including Hepato-biliary-pancreatic disorders
29. Mental health/ Neuro-psychiatric diseases
30. Regional and Occupational diseases
Section V: Health genomics of the South Asia
31. The organisation and function of clinical genomics & genetic counselling
32. Genome laboratories and Genome database systems
33. Fertility and Assisted Reproduction
34. Fetal Medicine and Newborn screening
35. Genetic and genomic education & training
36. Public and Population health genomics of the Indian subcontinent
37. Human genomics in Sri Lanka- from clinics to community
38. Clinical and Molecular genetic initiatives in Nepal
39. Medical and population genomics in Pakistan
40. Medical genetics and genetic counselling in Bangladesh
41. Human genomic disease specific database development- the model of the Global Globin database
42. Lay people & Public awareness and outreach
43. Religion and socio-cultural perspectives
44. Ethical, Legal and Social Issues (ELSI)
45. Glossary
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