Mechanical Circulatory and Respiratory Support, Second Edition, continues to provide a comprehensive overview of the past, present and future development of mechanical circulatory and respiratory support devices. This new edition provides an update on the field while also introducing new elements within the field such as ex-vivo perfusion, devices for HFpEF, design for manufacture, oxygenator design, and more content on route to market. Chapters from over 60 internationally-renowned experts focuses on the entire life-cycle of mechanical circulatory and respiratory support – from the descent into heart and lung failure, alternative medical management, device options, device design, implantation techniques, complications and medical management of the supported patient, patient-device interactions, cost effectiveness, route to market and a view to the future. This second edition is a useful resource for biomedical engineers and clinicians who are designing new mechanical circulatory or respiratory support devices, while also providing a comprehensive guide of the entire field for those who are already familiar with some areas and want to learn more. Reviews of the most cutting-edge research are provided throughout each chapter, along with guides on how to design new devices and which areas require specific focus for future research and development.
Section 1 – Heart Failure and Non-device Treatment
1. The Descent into Heart and Lung Failure
2. Heart and Lung Transplantation
3. Ex-vivo Organ Support
Section 2 – Types of Cardio-Respiratory Devices
4. Ventricular Assist Devices: Volume Displacement Pumps
5. Ventricular Assist Devices: Rotary Blood Pumps
6. Total Artificial Hearts
7. Devices for HFpEF
8. Extracorporeal Membrane Oxygenation
9. Pediatric Devices
Section 3 – Pump Design
10. Hydraulic Design
11. Motor design and Impeller Suspension
12. Design for Manufacture
13. Pulsatile vs Continuous Flow
14. Preclinical Evaluation
Section 4 - Implantation and Medical Management
15. Optimising the Patient and Timing the Introduction of MCS
16. Surgical Implantation
17. Complications and Adverse Events
18. Medical Management of the Supported Patient
Section 5 - Physiological Interaction between the Device and Patient
19. Cannula Design
20. Blood-Device Interaction
21. Physiological Control
22. Systems for Power and Data Transfer
23. Oxygenator Design
24. Wearable Systems
Section 6 – Route to Market (And Staying There!)
25. Route to Market
26. Clinical Trials
27. Cost Effectiveness
28. Regulatory Approvals
29. Reimbursement
Section 7 – Summaries
30. The Past, Present and Future
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