The concomitant existence of degenerative disease of the hip and spine (Hip-Spine Syndrome) is a common clinical finding. While special attention to Hip-Spine Syndrome and its surgical implications is becoming increasingly common among orthopedic and neurosurgical practitioners, there is still a great deal of controversy surrounding best practices, surgical considerations, and surgical execution.This book reviews the clinical entity of Hip-Spine Syndrome, presents approaches to management with a focus on surgical indications and considerations, and identifies areas that require further research.