This book discusses the mechanism and therapeutic strategies of phytochemicals against brain ageing. It discusses the underlying anti-oxidative and anti-inflammatory mechanisms of the phytochemicals and the implications of these compounds in the prevention and treatment of geriatric diseases. It discusses the potential role of the highly complex interactive network between the gut and the brain in neurodegenerative diseases such as Parkinson’s disease (PD), and Alzheimer’s disease. The chapters provide insight into the mechanisms involved in brain ageing and the mechanism of actions of the phytochemicals that might be crucial in developing effective new therapies against brain ageing. The chapter also presents the mechanisms of action of phytoconstituents, bioavailabilities, and their effects on neuroinflammation. The chapters also examine the phytochemicals protection of neurons via targeting oxidative stress, mitochondrial dysfunction, neurotrophic factor deficit, apoptosis, and abnormal protein accumulation. This book aims to provide comprehensive and cutting-edge information on the potential neuroprotective role of phytochemicals on the brain and neurological disorders to researchers, neuroscientists, clinical nutritionists, and physicians.
Chapter-1 Phytochemicals as potential protective agents for brain aging.- Chapter-2 Molecular mechanism of brain aging: Protective effects of phytochemicals.- Chapter-3 Response of cellular stress towards the hormetic phytochemicals in brain aging.- Chapter-4 Synergistic effects of multifunctional phytochemicals modulating the cellular signal pathways- as neuroprotective therapeutic approach for neurodegenerative disorders.- Chapter-5 Impact of aging, lifestyle, and phytochemicals on the commencement of neurological diseases.- Chapter-6 Recent Advancement in medicinal chemistry in formulations of phytochemicals against brain aging.- Chapter-7 Repurposing of Drugs in brain Aging.- Chapter-8 Ethanopharmacology: A boon for aging brain.- Chapter-9 Natural extracts and phytochemicals: Secondary metabolites of plants and the improvement of brain function.- Chapter-10 Flavonoids: A promosing Neuroprotectants and its Salutary Effects on age-related neurodegenerative disorders.- Chapter-11 Bioactive compounds of algae: Potential neuroprotective agents in neurodegenerative disorders.- Chapter-12 Phytochemical supplementation modulates cell survival signaling and regulates immune function through sympathetic innervation in ageing.- Chapter-13 POTENTIAL EFFECTS OF HUMAN ANTI-AGING COMPOUNDS: IMPLICATIONS ON BRAIN AGING.- Chapter-14 Advantages and disadvantages of current therapeutics and phytochemicals in age-related brain disorders.- Chapter-14 Advantages and disadvantages of current therapeutics and phytochemicals in age-related brain disorders.- Chapter-16 The controversy surrounding drugs against Neurodegeneration: Benefit or Harm?.
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