Iron-sulfur clusters are essential protein cofactors whose deficiency and defects lead to severe diseases and dysfunction of multiple cellular functions ranging from energy conversion to redox signaling. Iron-sulfur proteins have been discovered in many biological processes including DNA replication and repair, RNA modification, protein synthesis, energy metabolism, and signal transduction, so understanding these complexes is important for further studies of a rapidly expanding group of metabolic pathways vital to all kingdoms of life. This book will summarize the significance of iron-sulfur clusters in evolution, healthy metabolic function and dysfunction, and the exciting discoveries of iron-sulfur proteins in diverse physiological pathways. The text, written by one of the world's leading experts on iron-sulfur science, is designed for advanced students and professionals in biochemistry, molecular biology and physiology.