Structural Biology of Amyloid Fibrils is a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases and their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states, alongside an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability and mechanisms of formation. This volume also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease. Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves, or the processes that generate them.
1. Introduction
2. SSNMR: Methods and Applications
3. Cryo-EM: methods and applications
4. Amyloid-beta oligomers and fibrils
5. a-Synuclein oligomers and fibrils
6. TDP-43 oligomers and fibrils
7. Tau oligomers and fibrils
8. Prion oligomers and fibrils
9. IAPP oligomers and fibrils
10. Example and effects of post-translational modifications in amyloid structure
(Part I)
11. Effect of post-translational modifications in Amyloid structure
(part II)
12. Chemical modifications and amyloid structure
13. Energy landscape of amyloid formation
14. Computational studies of amyloid fibrils
15. Computational models of amyloid fibrils
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