Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research.
Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.
PART I GLYCOLYSIS AND PHYSIOLOGICAL PROCESSES
1. Development and glycolysis dependence
2. Neuro-glia communication and glycolysis
3. Glycolysis and skeletal muscle plasticity
4. Glycolysis and trained heart
5. Bone glycolysis and the regulation of energy balance
6. Glycolysis in adipose tissue-dependent thermogenesis
7. Regulation of glycolysis from a liver-centric perspective
8. Glycolysis as a rheostat mechanism in pancreas function
9. The Warburg-like effect in reproductive events
PART II GLYCOLYSIS AND PATHOLOGICAL EVENTS
10. Exploring glycolytic adaptations in cancer cells
11. The glycolytic pathway to heart failure
12. Glycolysis in PAH and COPD metabolic reprogramming
13. Glycolysis and mitochondrial function in diabetes mellitus
14. Metabolic adaptation to glycolysis as a basic defense mechanism of immune cells
15. Inborn glycolytic pathway defects
16. Enhanced glycolysis and metabolic complications of hematologic malignancies
17. Implications of glycolysis for osteoporosis pathogenesis
18. Glucose, glycolysis, and neurodegenerative diseases
19. Viral Infections and glycolysis
SUPPLEMENTAL INFORMATION – Methodological approaches
20. The application of Omics to explore glycolysis
21. An interactive analysis of glycolysis regulation
22. Measuring glycolysis flux
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