Biomarkers in Kidney Transplantation
Clinical Aspects and Laboratory Determination

By (author) Dr Smita Pattanaik,Dr Ashish Sharma

ISBN13: 9780128240694

Imprint: Academic Press Inc

Publisher: Elsevier Science Publishing Co Inc

Format:

Published: 01/12/2024

Availability: Not yet available

Description
Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers. Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.
1. Organ transplantation: Past, Present and Future 2. Trends in organ transplantation 3. Immunobiology in organ transplantation 4. Immunosuppression in solid organ transplantation 5. Challenges in therapeutic drug monitoring of immunosuppressants 6. Biomarkers in transplantation: An overview 7. Biomarkers for risk of rejection 8. Biomarkers predicting the response to immunosuppressant therapy 9. Biomarkers predicting risk of recurrence of the primary renal disease 10. Biomarkers for detecting opportunistic infections 11. Biomarkers detecting organ toxicity with immunosupressant drugs 12. Biomarkers for drug development in organ transplantation 13. Commercially available biomarkers for renal transplantation 14. The current challenges, unmet need and future directions
  • Renal medicine & nephrology
  • Transplant surgery
  • Life sciences: general issues
  • Professional & Vocational
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List Price: £115.00