This unique work compiles the latest knowledge around veterinary nutraceuticals, commonly referred to as dietary supplements, from ingredients to final products in a single source. More than sixty chapters organized in seven sections collate all related aspects of nutraceutical research in animal health and disease, among them many novel topics: common nutraceutical ingredients (Section-I), prebiotics, probiotics, synbiotics, enzymes and antibacterial alternatives (Section-II), applications of nutraceuticals in prevention and treatment of various diseases such as arthritis, periodontitis, diabetes, cognitive dysfunctions, mastitis, wounds, immune disorders, and cancer (Section-III), utilization of nutraceuticals in specific animal species (Section-IV), safety and toxicity evaluation of nutraceuticals and functional foods (Section-V), recent trends in nutraceutical research and product development (Section-VI), as well as regulatory aspects for nutraceuticals (Section-VII). The future of nutraceuticals and functional foods in veterinary medicine seems bright, as novel nutraceuticals will emerge and new uses of old agents will be discovered.
International contributors to this book cover a variety of specialties in veterinary medicine, pharmacology, pharmacognosy, toxicology, chemistry, medicinal chemistry, biochemistry, physiology, nutrition, drug development, regulatory frameworks, and the nutraceutical industry. This is a highly informative and carefully presented book, providing scientific insight for academia, veterinarians, governmental and regulatory agencies with an interest in animal nutrition, complementary veterinary medicine, nutraceutical product development and research.
PRELIMINARY _03_2018
IntroductionRamesh C. Gupta, Murray State University, Hopkinsville, KY, USA; and Ajay Srivastava and Rajiv Lall, Vets Plus Inc, Menomonie, WI, USAEmail: rgupta@murraystate.edu; drajay@vets-plus.com; lallr@vets-plus.com
I. COMMON NUTRACEUTICALS
1. Curcumin/TurmericNaresh Chand, National Institutes of Health, Bathesda, MD, USAEmail: nchand@mail.nih.govAndSally Frautschy, University of California Los Angeles, Los Angeles, CA, USAEmail: sfrautschy@mednet.ucla.edu
2. FenugreekDinesh Kumar, W. Ramdas Singh, Anu Rahal, and Jitendra K. MalikIndian Veterinary Research Institute, Izatnagar, Bareilly, India Email: dineshks17@gmail.com
3. AshwagandhaVijay K. Bharti, Jitendra K. Malik, and Ramesh C. Gupta Defense Institute of High Altitude Research (DIHAR), DRDO, Leh, IndiaEmail: vijaykbharti@rediffmail.com
4. ShilajitShailesh K. Bhavsar*, Aswim M. Thaker, and Jitendra K. MalikAnand Agricultural University, Anand, IndiaEmail: skbhavsar@yahoo.com
5. Seabuckthorne and ApricotVijay K. Bharti Defense Institute of High Altitude Research (DIHAR), DRDO, Leh, India Email: vijaykbharti@rediffmail.com
6. GingerShyam S. Sharma and K. Srinivasan, Dept. Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, Mohali, IndiaEmail: sssharma@niper.ac.in
7. Neem extractJitendra K. Malik, Former Joint Director (Research), and Head of the Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Bareilly, Dehradun, Uttarakhand, India Email: jkmalik48@gmail.com
8. Omega fatty acidsSzabina A. Stice, Division of Biotechnology and GRAS Notice Review, FDA, College Park, MD, USAE-mail: szabina.stice@fda.hhs.gov
9. L-Tryptophan and 5-HTPAjay Srivastava, Vets Plus Inc, Menomonie, WI, USAEmail: drajay@vets-plus.com
10. BerberineRamesh C. Gupta, Murray State University, Hopkinsville, KY, USAEmail: rgupta@murraystate.edu
11. Glucosinolates and organosulfur compoundsKaryn Bischoff, Cornell University, Ithaca, NY, USAEmail: klb72@cornell.edu
12. Nutraceutical values of red mold rice for anti-diabetic and anticlastogenic propertiesJacob A. C. Sanchez, Pampanga State Agricultural University, Pampanga, PhilippinesEmail: jacobsanchezph1@gmail.edu
13. Medium Chain TriglyceridesYet to be assigned Email:
14. Colostrum and Immunoglobulins Dan Duberdieu, Vets Plus Inc, Menomonie, WI, USA Email: dand@vets-plus.com
15. Herbal Marijuana/Cannabis sativaJoshua A. Hartsel, Delta-9 Technologies, LLC, Lake Forest, CA, USAEmail: jhartsel@gmail.edu 16. Juniper Rajinder Raina, Pawan K. Verma, Jitendra K. Malik, and Ramesh C. Gupta Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu, India Email: drrajinderraina@ymail.com
17. Natural preservatives and food additivesAjay Srivastava and Tapan Gor, Vets Plus Inc, Menomonie, WI, USAEmail: drajay@vets-plus.com
18. Antioxidants in animal health Yogendra K. Gupta, All India Institute of Medical sciences. New Delhi, IndiaEmail: ykgykg@gmail.com or ykg@hotmail.com 19. Polyphenols and flavonoids Satish K. Garg, Soumen Choudhury and Amit Shukla U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, India Email: profsatish@gmail.com
II. PREBIOTICS, PROBIOTICS, SYNBIOTICS, AND ANTIMICROBIALS
20. Prebiotics and probiotics in feed and animal health Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain Email: anadon@vet.ucm.es
21. Synbiotics in animals health Jitendra K. Malik and Ramesh C. Gupta Former Joint Director (Research), and Head of the Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Bareilly, Dehradun, Uttarakhand, India Email: jkmalik48@gmail.com
22. Enzymes in feed and animal health Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain Email: anadon@vet.ucm.es
23. Optimization of mineral supplements for maximized animal productivityJeffery O. Hall, Utah State University, Logan, UT, USAEmail: jeffery.hall@usu.edu
24. Nutraceuticals used as antibacterial alternatives in animal health Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain Email: anadon@vet.ucm.es
25. Feed additives in animal healthPrafull Kumar and M.J. Saxena, Ayurvet, Ghaziabad, UP, IndiaEmail: pverma@ayurvet.com; mjsaxena@ayurvet.com
III. NUTRACEUTICALS IN ORGAN/SYSTEM DISORDERS
26. Nutraceuticals in arthritisRamesh C. Gupta, Murray State University, Hopkinsville, KY, USAE-mail: rgupta@murraystate.edu
27. Nutraceuticals in oral health and periodontal diseases Yet to be assigned Email:
28. Nutraceuticals in gastrointestinal conditionsJamil Talukder, Vets Plus Inc, Menomonie, WI, USAEmail: jamilt@vets-plus.com
29. Nutraceuticals in hepatic and pancreatic diseasesSharon Gwaltney-Brant, University of Illinois, Urbana-Champaign, IL, USAEmail: sharon.brant@mchsi.com
30. Nutraceuticals in genitourinary diseasesRobert W. Coppock, Toxicologist and Assoc Ltd, Vegreville, AB, Canada, USAEmail: r.coppock@toxicologist.ca
31. Nutraceuticals in cardiovascular diseasesCsaba Zoltani, Emeritus US Army Research Lab, Aberdeen Proving Ground, MD, USAEmail: c.zoltani@gmail.com
32. Nutraceuticals in respiratory diseasesAjay Srivastava, Vets Plus Inc, Menomonie, WI, USAEmail: drajay@vets-plus.com
33. Nutraceuticals in reproductive disordersMoges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USAEmail: mwoldem@uga.edu
34. Nutraceuticals in dermatological disordersMoges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USAEmail: mwoldem@uga.edu
35. Nutraceuticals in mastitis Robert W. Coppock, Toxicologist and Assoc Ltd, Vegreville, AB, Canada, USA Email: r.coppock@toxicologist.ca
36. Nutraceuticals in immune disordersMoges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USAEmail: mwoldem@uga.edu
37. Nutraceuticals for wound healingAjay Srivastava, Vets Plus Inc, Menomonie, WI, USAEmail: drajay@vets-plus.com
38. Nutraceuticals for calming and stress Yet to be assigned Email:
39. Nutraceuticals for cognitive dysfunctionRamesh C. Gupta, Murray State University, Hopkinsville, KY, USAEmail: rgupta@murraystate.edu
40. Nutraceuticals for antiagingYet to be assigned Email:
41. Nutraceuticals in cancer prevention and cure Subhash C. Gupta, Banaras Hindu University, Banaras, UP, IndiaEmail: subhashg167@gmail.com
42. Nutraceuticals alone or in combination with chemotherapeutic agents for prevention and treatment of cancerM. Waheed Roomi, Dr Rath Research Institute, Santa Clara, CA, USAEmail: w.roomi@drrath.com
43. Nutraceuticals in obesity and metabolic disordersRhian B. Cope, Health Product Regulation Group, Woden ACT, AustraliaEmail: rhian.Cope@health.gov.au
44. Nutraceuticals for ticks, fleas and other ectoparasitesRamesh C. Gupta, Murray State University, Hopkinsville, KY, USAEmail: rgupta@murraystate.edu
45. Nutraceuticals in hunting, sporting and performance enhancing activitiesYet to be assigned Email:
IV. NUTRACEUTICALS IN SPECIFIC ANIMAL SPECIES
46. Nutraceuticals in cattle health and diseasesAyhan Filazi and Begum Yurdakok Dikmen, Ankara University, Ankara, TurkeyEmail: afilazi@gmail.com
47. Nutraceuticals in equine health and diseasesYet to be assigned Email:
48. Nutraceuticals in camelids Tarun K. Gahlot, Bikaner Veterinary Science University, Bikaner, India Email: tkcamelvet@yahoo.com
49. Nutraceuticals in poultry health and diseases Begum Yurdakok Dikmen and Ayhan Filazi, Ankara University, Ankara, TurkeyEmail: byurdakok@yahoo.com
V. SAFETY AND TOXICITY EVALUATION OF FUNCTIONAL FOODS AND NUTRACEUTICALS
50. Safety and toxicity evaluation of nutraceuticals in animal modelsNikolay Goncharov, Russian Academy of Sciences, Saint Petersburg, RussiaEmail: ngoncharov@gmail.com
51. Safety and toxicity evaluation of nutraceuticals using alternative in vitro models Subhash C. Gupta, Banaras Hindu University, Banaras, UP, IndiaEmail: subhashg167@gmail.com
52. Safety of pet food, functional food, and nutraceuticalsSandra James-Yi, Now Health Group, Inc., Bloomingdale, IL, USAEmail: Sandra.james-yi@nowfoods.com
53. Hydrocolloids: safety and toxicity considerationsLarry J. Thompson, Nestle Purina PetCare, St. Louis, MO, USAEmail: larry.thompson@rdmo.nestle.com
54. Biomarkers for selected foods and nutraceuticalsRamesh C. Gupta, Murray State University, Hopkinsville, KY, USAEmail: rgupta@murraystate.edu
55. Toxic interaction of nutraceuticals with food and pharmaceuticals Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA Email: rgupta@murraystate.edu Rhian B. Cope, Health Product Regulation Group, Woden ACT, Australia Email: rhian.Cope@health.gov.au
VI. NUTRACEUTICAL PRODUCT DEVELOPMENT
56. Nutraceuticals palatability process and studyAjay Srivastava, Vets Plus Inc, Menomonie, WI, USA Email: drajay@vets-plus.com
57. Steps to conduct nutraceutical clinical efficacy trials Isabelle Mougeot, CanCog technologies Inc, Toronto, ON, CanadaEmail: isabellem@cancog.com
58. Nutraceuticals stability studyDan Duberdieu, Vets Plus Inc, Menomonie, WI, USAEmail: dand@vets-plus.com
VII. NEWER TRENDS IN NUTRACEUTICAL RESEARCH
59. Nanosupplements and animal healthFrancesca Caloni, Universita degli Studi di Milano, Milan, ItalyEmail: francesca.caloni@unimi.it
60. Fabrication and use of nanoparticles in delivery of dietary ingredients and nutraceuticals to biological systemGianfranco Risuleo, Sapienza University of Rome, Rome, ItalyEmail: gianfranco.risuleo@gmail.com
61. Proteomics in evaluation of nutraceuticals and functional foodChristina R. Wilson, Dept. Comparative Pathology, Purdue University, West Lafayette, IN, USAEmail: wilsonc@purdue.edu
62. Bioavailability of nutraceuticalsGianfranco Risuleo, Sapienza University of Rome, Rome, ItalyEmail: gianfranco.risuleo@gmail.com
VIII. REGULATORY ASPECT OF NUTRACEUTICALS
63. Role of AAFCO in functional food and nutraceutical regulationsAnita Sinha and Bill Bookout , Vets Plus Inc, Menomonie, WI, USAEmail: anitas@vets-plus.com and b.bookout@nasc.cc
64. Role of NASC in functional food and nutraceutical regulationsBill Bookout and Anita Sinha, Vets Plus Inc, Menomonie, WI, USAEmail: b.bookout@nasc.cc and anitas@vets-plus.com
65. Regulatory guidelines for nutraceuticals in the EUDoriana Tedesco, Milano University, Milano, ItalyEmail: Doriana.tedesco@unimi.it
66. US FDA’s perspective in regulation of veterinary nutraceuticals Daljit Vudathala, University of Pennsylvania, Kennet Square, PA, USAEmail: vudathal@vet.upenn.edu
67. Regulatory guidelines for nutraceuticals in Australia and New Zealand Rhian B. Cope, Health Product Regulation Group, Woden ACT, Australia Email: rhian.Cope@health.gov.au
68. Regulatory guidelines for nutraceuticals and food supplements in India Pawan K. Gupta, Bareilly, India Email: drpkg_brly@yahoo.co.in
69. Regulatory guidelines for nutraceuticals in ChinaYet to be assigned Email:
70. Regulatory guidelines for nutraceuticals and food supplements in Turkey Begum Yurdakok Dikmen, and Ayhan Filazi, Ankara University, Ankara, Turkey Email: byurdakok@yahoo.com
71. Uses and regulatory guidelines of nutraceuticals in PhilippinesJacob A. C. Sanchez, Pampanga State Agricultural University, Pampanga, PhilippinesEmail: jacobsanchezph1@gmail.com
72. Regulatory guidelines for nutraceuticals in South AmericaYet to be assigned Email:
73. Regulatory guidelines for nutraceuticals in South AfricaVinny Naidoo, University of Pretoria, Onderstepoort, Republic of South AfricaEmail: vinny.naidoo@up.ac.za