This textbook is relevant to BSc/MSc students interested in mathematical modeling and simulation. It brings together analysis, calculus and numerical methods presented in a single coherent volume. Particular attention is given to engineering mathematics, addressing modeling, analysis, method development, implementation and testing of algorithms, as well as application to actual problems and critical interpretation of the results. The book can be used throughout bachelor programs and parts of masters programs, presenting a comprehensive suite of courses that link formal abstract thinking on the one hand to intuitive model formulation, critical algorithm development and interpretation of results on the other hand. The books contains numerous examples of practical applications from physics, technology, biology and chemistry. It also contains an introduction to Matlab and C for algorithm development and computational analysis. Software and solutions to selected problems are included.