Clinical Pharmacology and Therapeutics Lecture Notes provides a clear and accessible overview of all the key prescribing topics needed for medical finals and beyond. Detailed coverage and discussion of pharmacology in a clinical context, combined with an easy-to-understand, readable style, helps improve and test understanding of pharmacological principles and reasoning on rotation and into the foundation years. Key features for this edition include: Clinical scenarios to root each chapter firmly in a real-life setting Prescribing points flagging up important issues of clinical relevance Expanded sections on drugs you may need in a hurry, prescribing and its pitfalls, and paediatric prescribing A self-assessment section to test your knowledge and help prepare for examinations Clinical Pharmacology and Therapeutics Lecture Notes is an ideal resource for all medical students, junior doctors, and other prescribers, whether learning how pharmacological principles relate to clinical situations, brushing up on the basics while on rotation, or looking for a comprehensive overview of prescribing and therapeutics.
Contributors, vi Preface, vii Foreword, ix Part 1 Principles of clinical pharmacology 1 Pharmacodynamics and pharmacokinetics, 3 2 Clinical trials and drug development, 11 Part 2 Aspects of therapeutics 3 Drugs and gastrointestinal disease, 19 4 Management of coronary artery disease and its complications, 29 5 Primary and secondary prevention of cardiovascular disease, 52 6 Drugs used to treat respiratory disease, 71 7 Drugs used to treat neurological disease, 81 8 Treatment of psychiatric disorders, 97 9 Antimicrobial therapy, 111 10 HIV and antiretroviral treatment, 132 11 Travel medicine and tropical disease, 143 12 Drugs and endocrine disease, 153 13 Drugs and the reproductive system, 169 14 Drugs and the urological system, 178 15 Cancer therapeutics, 185 16 Drugs and infl ammatory joint disease, 197 17 Immunopharmacology, 204 18 Drugs and the blood including anticoagulants and thrombolytic drugs, 215 19 Drugs used for pain relief and anaesthesia, 228 Part 3 Practical aspects of prescribing 20 Clinical pharmacokinetics: dosage individualisation, 241 21 Influence of renal and hepatic disease on pharmacokinetics and pharmacodynamics, 247 22 Prescribing for the young and the elderly, 252 23 Drugs in pregnant and breastfeeding women, 255 24 Pharmacoeconomics: the economic evaluation of new drugs, 262 25 Poisoning and drug overdose, 269 26 Drugs you may need in a hurry, 283 27 Prescribing and its pitfalls, 287 Self assessment questions, 294 Self assessment answers, 299 Index, 302
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