Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease: From Basic Science to Clinical Application presents the latest information on the contributions of different FABPs in physiology and pathophysiology, along with their importance in clinical outcomes. The book is divided into six main sections that cover FABP biology and their role in inflammation and diseases, such as cardiovascular, neurological, and liver diseases, to FABPs and their clinical applications. Each chapter thoroughly reviews current literature, primary research data and clinical cases, providing readers with an overview of the latest information in the expanded field of FABPs. This is an invaluable resource for both researchers and clinicians familiar with and those new to the exciting and everchanging world of fatty acid-binding proteins and clinical disorders.
Section 1: Overview of FABP biology 1. Introduction to FABP family, tissue expression & ligand specificity 2. FABP expression and regulation, structure homology with other proteins 3. Structure and functions of FABPs and other similar proteins such as SCP2, and alpha-synuclein 4. FABPs in cell signaling, angiogenesis, and gene expression 5. FABPs in cardiac remodeling 6. Impacts of dietary lipids on FABPs and cell growth 7. FABP and endocannabinoid metabolism in the liver and brain Section 2: FABPs and inflammation 8. FABPs in inflammatory diseases 9. FABPs in immune cell functions 10. Roles of FABPs in brain inflammation 11. FABP in adipose tissue inflammation Section-3: FABPs in metabolic disorders & Obesity 12. FABPs in the development of insulin resistance and diabetes 13. FABPs in the development and progression of cardiovascular diseases 14. FABPs and metabolic syndrome 15. Role of FABPs in obesity Section-4: FABPs and human diseases 16. FABPs dysregulation and human diseases 17. FABPs and brain diseases 18. FABPs and liver diseases 19. FABPs and developmental diseases 20. FABPs in reperfusion injury in tissues 21. FABPs in celiac diseases Section 5: FABPs and Cancers 21. Diverse roles of FABPs in the development of cancers 22. FABPs in Prostate, bladder and kidney cancers 23. Capter-24: FABPs in psoriasis 24. FABPs and breast cancers Section 6: FABPs in Clinical applications 25. Plasma FABPs as biomarkers of diseases 26. Clinical usefulness of urinary FABPs in assessing several diseases 27. FABPs as therapeutic targets in different diseases
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