Tomlinson-Online - Holland-Frei Cancer Medicine

HOLLAND-FREI CANCER MEDICINE The latest edition of the gold-standard in cancer science and clinical oncology references In the newly revised Tenth Edition of Holland-Frei Cancer Medicine, a team of distinguished researchers and practitioners delivers a comprehensive and up-to-date discussion of cancer science and clinical oncology practice. The book contains timely and indispensable information on epidemiology, etiology, cancer biology, immunology, prevention, screening, clinical presentation, pathology, imaging, and therapy. Grounded in a fundamental understanding of cancer biology, Holland-Frei Cancer Medicine combines scientific principles with clinical practice. It contains hundreds of full-color illustrations and photographs, tables, graphs, and algorithms that complement and enhance the complex topics discussed within the book. This book is an invaluable clinical tool that provides readers with overview boxes, additional references, and other pedagogic features designed to make the content easy to access and comprehend. Readers will also find: A translational and integrated approach throughout the book that combines cancer biology with cancer management A strong emphasis on multidisciplinary, research-driven patient care that improves outcomes and allows for the optimal use of all clinically appropriate therapies Discussions of the most current personalized cancer care, including molecular diagnostics and therapeutics Perfect for medical oncologists, radiation oncologists, and internists, Holland-Frei Cancer Medicine, Tenth Edition will also earn a place in the libraries of allied health professionals involved in the treatment of cancer patients. This book is published in collaboration with the American Association for Cancer Research: https://www.aacr.org/

List of contributors xi Preface xxvii Acknowledgments xxix Part 1: INTRODUCTION 1 Cardinal manifestations of cancer 3 James F. Holland, Robert C. Bast, Jr., John C. Byrd, Carlo M. Croce, Ernest Hawk, Fadlo R. Khuri, Raphael E. Pollock, Apostolia M. Tsimberadou, Christopher G. Willett, and Cheryl L.Willman 2 Biological hallmarks of cancer 7 Douglas Hanahan and Robert A.Weinberg Part 2: TUMOR BIOLOGY 3 Molecular biology, genetics, and translational models of human cancer 19 Benno Traub, Florian Scheufele, Srinivas R. Viswanathan, Matthew Meyerson, and David A. Tuveson 4 Oncogenes 49 Marco A. Pierotti, Milo Frattini, Samantha Epistolio, Gabriella Sozzi, and Carlo M. Croce 5 Tumor suppressor genes 73 Fred Bunz and Bert Vogelstein 6 Epigenetic contributions to human cancer 89 Stephen B. Baylin 7 Cancer genomics and evolution 101 William P. D. Hendricks, Aleksandar Sekulic, Alan H. Bryce, Muhammed Murtaza, Pilar Ramos, Jessica D. Lang, Timothy G. Whitsett, Timothy K. McDaniel, Russell C. Rockne, Nicholas Banovich, and Jeffrey M. Trent 8 Chromosomal aberrations in cancer 125 Megan E. McNerney, Ari J. Rosenberg, and Michelle M. Le Beau 9 MicroRNA expression in cancer 143 Serge P. Nana-Sinkam, Mario Acunzo, and Carlo M. Croce 10 Aberrant signaling pathways in cancer 151 Luca Grumolato and Stuart A. Aaronson 11 Differentiation therapy 161 Sai-Juan Chen, Xiao-Jing Yan, Guang-Biao Zhou, and Zhu Chen 12 Cancer stem cells 177 Grace G. Bushnell,Michael D. Brooks, andMax S.Wicha 13 Cancer and cell death 187 John C. Reed 14 Cancer cell immortality: targeting telomerase and telomeres 201 Ilgen Mender, Zeliha G. Dikmen, and JerryW. Shay 15 Cancer metabolism 211 Natalya N. Pavlova, Aparna D. Rao, Ralph J. DeBerardinis, and Craig B.Thompson 16 Tumor angiogenesis 223 John V. Heymach, Amado Zurita-Saavedra, Scott Kopetz, Tina Cascone, MoniqueNilsson, and IreneGuijarro Part 3: QUANTITATIVE ONCOLOGY 17 Cancer bioinformatics 247 John N.Weinstein 18 Systems biology and genomics 261 Saima Hassan, Joe W. Gray, and LauraM.Heiser 19 Statistical innovations in cancer research 269 J. Jack Lee and Donald A. Berry 20 Biomarker based clinical trial design in the era of genomic medicine 285 R.Donald Harvey, Yuan Liu, Taofeek K.Owonikoko, and Suresh S. Ramalingam 21 Clinical and research informatics data strategy for precision oncology 293 Douglas Hartman, Uma Chandran, Michael Davis, Rajiv Dhir,William E. Shirey, Jonathan C. Silverstein, and Michael J. Becich Part 4: CARCINOGENESIS 22 Chemical carcinogenesis 305 Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris 23 Ionizing radiation 325 David J. Grdina 24 Ultraviolet radiation carcinogenesis 333 James E. Cleaver, Susana Ortiz-Urda, and Sarah Arron 25 Inflammation and cancer 339 Jelena Todoric, Atsushi Umemura, Koji Taniguchi, and Michael Karin 26 RNA tumor viruses 347 Robert C. Gallo and Marvin S. Reitz 27 Herpesviruses 359 Jeffrey I. Cohen 28 Papillomaviruses and cervical neoplasia 367 Michael F. Herfs, Christopher P. Crum, and KarlMunger 29 Hepatitis viruses and hepatoma 373 HongyangWang 30 Parasites 379 Mervat El Azzouni, Charbel F. Matar, Radwa Galal, Elio Jabra, and Ali Shamseddine Part 5: EPIDEMIOLOGY, PREVENTION, AND DETECTION 31 Cancer epidemiology 391 Veronika Fedirko, Kevin T. Nead, Carrie Daniel, and Paul Scheet 32 Hereditary cancer syndromes: risk assessment and genetic counseling 403 Rachel Bluebond, Sarah A. Bannon, Samuel M. Hyde, Ashley H.Woodson, Nancy Y.-Q. You, Karen H. Lu, and Banu Arun 33 Behavioral approaches to cancer prevention 425 Roberto Gonzalez and Maher Karam-Hage 34 Diet and nutrition in the etiology and prevention of cancer 433 Steven K. Clinton, Edward L. Giovannucci, Fred K. Tabung, and Elizabeth M. Grainger 35 Chemoprevention of cancer 453 Ernest Hawk, Karen C. Maresso, Powel Brown, Michelle I. Savage, and Scott M. Lippman 36 Cancer screening and early detection 473 OtisW. Brawley Part 6: CLINICAL DISCIPLINES 37 Clinical cancer genomic diagnostics and modern diagnostic pathology 493 Katherine Roth, Stephen B. Gruber, and Kevin McDonnell 38 Molecular diagnostics in cancer 505 Zachary L. Coyne, Roshni D. Kalachand, Robert C. Bast Jr., Gordon B. Mills, and Bryan T. Hennessy 39 Principles of imaging 519 Lawrence H. Schwartz 40 Interventional radiology for the cancer patient 521 Zeyad A. Metwalli, Judy U. Ahrar, andMichael J. Wallace 41 Principles of surgical oncology 531 ToddW. Bauer, Kenneth K. Tanabe, and Raphael E. Pollock 42 Principles of radiation oncology 543 Scott R. Floyd, Justus Adamson, Philip P. Connell, Ralph R.Weichselbaum, and Christopher G.Willett 43 Principles of medical oncology 553 Apostolia M. Tsimberidou, Robert C. Bast, Jr., Fadlo R. Khuri, and John C. Byrd 44 Pain and palliative care 567 Laura Van Metre Baum and Cardinale B. Smith 45 Psycho-oncology 577 Diya Banerjee and Andrew J. Roth 46 Principles of cancer rehabilitation medicine 585 Michael D. Stubblefield, Miguel Escalon, Sofia A. Barchuk, Krina Vyas, and David C.Thomas 47 Integrative oncology in cancer care 593 Gabriel Lopez,Wenli Liu, Santhosshi Narayanan, and Lorenzo Cohen 48 Health services research 599 Michaela A. Dinan and Devon K. Check Part 7: INDIVIDUALIZED TREATMENT 49 Precision medicine in oncology drug development 613 Apostolia M. Tsimberidou, Elena Fountzilas, and Razelle Kurzrock Part 8: CHEMOTHERAPY 50 Drug development of small molecule cancer therapeutics in an Academic Cancer Center 631 Christopher C. Coss, Jeffrey T. Patrick, Damien Gerald, Gerard Hilinski, Reena Shakya, and John C. Byrd 51 Principles of dose, schedule, and combination therapy 641 Joseph P. Eder and Navid Hafez 52 Pharmacology of small-molecule anticancer agents 655 Zahra Talebi, Sharyn D. Baker, and Alex Sparreboom 53 Folate antagonists 667 Lisa Gennarini, Peter D. Cole, and Joseph R. Bertino 54 Pyrimidine and purine antimetabolites 679 Robert B. Diasio and StevenM. Offer 55 Alkylating agents and platinum antitumor compounds 693 Zahid H. Siddik 56 DNA topoisomerase targeting drugs 701 AnishThomas, Susan Bates,William D. Figg, Sr., and Yves Pommier 57 Microtubule inhibitors 717 Giuseppe Galletti and Paraskevi Giannakakou 58 Drug resistance and its clinical circumvention 731 Jeffrey A. Moscow, Shannon K. Hughes, Kenneth H. Cowan, and Branimir I. Sikic Part 9: BIOLOGICAL AND GENE THERAPY 59 Cytokines, interferons, and hematopoietic growth factors 739 Narendranath Epperla,Walter Hanel, and Moshe Talpaz 60 Monoclonal antibody and targeted toxin therapy 755 Robert C. Bast, Jr. andMichael R. Zalutsky 61 Vaccines and immunomodulators 781 Jeffrey Schlom, Sofia R. Gameiro, Claudia Palena, and James L. Gulley 62 T cell immunotherapy of cancer 789 M. Lia Palomba, Jae H. Park, and Renier Brentjens 63 Cancer immunotherapy 799 Padmanee Sharma, Swetha Anandhan, Bilal A. Siddiqui, Sangeeta Goswami, Sumit K. Subudhi, Jianjun Gao, Karl Peggs, Sergio Quezada, and James P. Allison 64 Cancer gene therapy 817 Haruko Tashiro, Lauren Scherer, and Malcolm Brenner 65 Cancer nanotechnology 825 Xingya Jiang, Yanlan Liu, Danny Liu, Jinjun Shi, and Robert Langer 66 Hematopoietic cell transplantation 833 Qaiser Bashir, Elizabeth J. Shpall, and Richard E. Champlin Part 10: SPECIAL POPULATIONS 67 Principles of pediatric oncology 847 Theodore P. Nicolaides, Elizabeth Raetz, andWilliam L. Carroll 68 Cancer and pregnancy 867 Jennifer K. Litton 69 Cancer and aging 877 Ashley E. Rosko, Carolyn J. Presley, Grant R.Williams, and Rebecca L. Olin 70 Disparities in cancer care 885 OtisW. Brawley 71 Neoplasms in people living with human immunodeficiency virus 895 Chia-Ching J.Wang and Elizabeth Y. Chiao 72 Cancer survivorship 911 Lewis Foxhall Part 11: DISEASE SITES 73 Primary neoplasms of the brain in adults 921 Matthew A. Smith-Cohn and Mark R. Gilbert 74 Neoplasms of the eye and orbit 933 Erica R. Alvarez, Claudia M. Prospero Ponce, Patricia Chevez-Barrios, and Dan S. Gombos 75 Neoplasms of the endocrine glands and pituitary neoplasms 943 Rui Feng, Chirag D. Gandhi, Margaret Pain, and Kalmon D. Post 76 Neoplasms of the thyroid 949 Matthew D. Ringel 77 Malignant tumors of the adrenal gland 961 Jeffrey E. Lee, Mouhammed A. Habra, andMatthew T. Campbell 78 Tumors of the diffuse neuroendocrine and gastroenteropancreatic system 971 Evan Vosburgh 79 Neoplasms of the head and neck 981 Robert L. Ferris, AdamS. Garden, andNabil F. Saba 80 Cancer of the lung 1005 Daniel Morgensztern, Daniel Boffa, Alexander Chen, Andrew Dhanasopon, Sarah B. Goldberg, Roy H. Decker, Siddhartha Devarakonda, Jane P. Ko, Luisa M. Solis Soto, Saiama N.Waqar, Ignacio I.Wistuba, and Roy S. Herbst 81 Malignant pleural mesothelioma 1029 Michele Carbone, Daniel R. Gomez, Anne S. Tsao, Haining Yang, and Harvey I. Pass 82 Thymomas and thymic tumors 1043 Mayur D. Mody,Gabriel L. Sica, Suresh S. Ramalingam, and Dong M. Shin 83 Tumors of the heart and great vessels 1055 Moritz C.Wyler von Ballmoos and Michael J. Reardon 84 Primary germ cell tumors of the thorax 1061 John D. Hainsworth and Frank A. Greco 85 Neoplasms of the esophagus 1065 MaxW. Sung and Virginia R. Litle 86 Carcinoma of the stomach 1083 Carl Schmidt, Nour Daboul, Carly Likar, and JoshuaWeir 87 Primary neoplasms of the liver 1095 Hop S. Tran Cao, Junichi Shindoh, and Jean-Nicolas Vauthey 88 Gallbladder and bile duct cancer 1109 Mariam F. Eskander, Christopher T. Aquina, and Timothy M. Pawlik 89 Neoplasms of the exocrine pancreas 1123 Robert A. Wolff, Donghui Li, AnirbanMaitra, Susan Tsai, Eugene Koay, and Douglas B. Evans 90 Neoplasms of the appendix and peritoneum 1139 Annie Liu, Diana Cardona, and Dan Blazer 91 Carcinoma of the colon and rectum 1147 Yota Suzuki, Douglas S. Tyler, and Uma R. Phatak 92 Neoplasms of the anus 1169 Alexandre A. A. Jácome and Cathy Eng 93 Renal cell carcinoma 1181 Claude M. Grigg, Earle F. Burgess, Stephen B. Riggs, Jason Zhu, and Derek Raghavan 94 Urothelial cancer 1191 Derek Raghavan, Richard Cote, Earle F. Burgess, Derek McHaffie, and Peter E. Clark 95 Neoplasms of the prostate 1201 Ana Aparicio, Patrick Pilie, Devaki S. Surasi, Seungtaek Choi, Brian F. Chapin, Christopher J. Logothetis, and Paul G. Corn 96 Tumors of the penis and the urethra 1239 Jad Chahoud, Andrea Necchi, and Philippe E. Spiess 97 Testis cancer 1245 Michael Hawking, Gladell Paner, Scott Eggener, and Walter M. Stadler 98 Neoplasms of the vulva and vagina 1261 Michael Frumovitz and Summer B. Dewdney 99 Neoplasms of the cervix 1275 Anuja Jhingran 100 Endometrial cancer 1299 Shannon N.Westin, Karen Lu, and Jamal Rahaman 101 Epithelial ovarian, fallopian tube, and peritoneal cancer 1311 Jonathan S. Berek, Malte Renz, Michael L. Friedlander, and Robert C. Bast, Jr. 102 Nonepithelial ovarian malignancies 1329 Jonathan S. Berek, Malte Renz, Michael L. Friedlander, and Robert C. Bast, Jr. 103 Molar pregnancy and gestational trophoblastic neoplasia 1343 Neil S. Horowitz, Donald P. Goldstein, and Ross S. Berkowitz 104 Gynecologic sarcomas 1351 Jamal Rahaman and Carmel J. Cohen 105 Neoplasms of the breast 1361 Debu Tripathy, Sukh Makhnoon, Banu Arun, Aysegul Sahin, Nicole M. Kettner, Senthil Damodaran, Khandan Keyomarsi,Wei Yang, Kelly K. Hunt, Mark Clemens, Wendy A. Woodward, Melissa P.Mitchell, Rachel Layman, Evthokia A. Hobbs, Bora Lim, MeganDupuis, Rashmi Murthy, Omar Alhalabi, Nuhad Ibrahim, Ishwaria M. Subbiah, and Carlos Barcenas 106 Malignant melanoma 1413 Michael J. Carr, JustinM. Ko, SusanM. Swetter, Scott E. Woodman, Vernon K. Sondak, Kim A. Margolin, and Jonathan S. Zager 107 Other skin cancers 1437 Stacy L. McMurray,William G. Stebbins, Eric A. Millican, and Victor A. Neel 108 Bone tumors 1451 Timothy A. Damron 109 Soft tissue sarcomas 1477 Katherine A.Thornton, Elizabeth H. Baldini, Robert G. Maki, Brian O’Sullivan, Yan Leyfman, and Chandrajit P. Raut 110 Myelodysplastic syndromes 1501 Uma M. Borate 111 Acute myeloid leukemia in adults: mast cell leukemia and other mast cell neoplasms 1517 RichardM. Stone, Charles A. Schiffer, and Daniel J. DeAngelo 112 Chronic myeloid leukemia 1537 Jorge Cortes, Richard T. Silver, and Hagop Kantarjian 113 Acute lymphoblastic leukemia 1547 Elias Jabbour, Nitin Jain, Hagop Kantarjian, and Susan O’Brien 114 Chronic lymphocytic leukemia 1559 Jacqueline C. Barrientos, Kanti R. Rai, and Joanna M. Rhodes 115 Hodgkin lymphoma 1569 David J. Straus and Anita Kumar 116 Clonal hematopoiesis in cancer 1579 Philipp J. Rauch and David P. Steensma 117 Non-Hodgkin’s lymphoma 1587 Arnold S. Freedman and Ann S. LaCasce 118 Mycosis fungoides and Sézary syndrome 1603 Walter Hanel, Catherine Chung, and John C. Reneau 119 Plasma cell disorders 1611 Andrew J. Yee, Teru Hideshima, Noopur Raje, and Kenneth C. Anderson 120 Myeloproliferative disorders 1633 Jeanne Palmer and Ruben Mesa Part 12: MANAGEMENT OF CANCER COMPLICATIONS 121 Neoplasms of unknown primary site 1647 John D. Hainsworth and Frank A. Greco 122 Cancer cachexia 1659 Assaad A. Eid, Rachel Njeim, Fadlo R. Khuri, and David K.Thomas 123 Antiemetic therapy 1673 Michael J. Berger andDavid S. Ettinger 124 Neurologic complications of cancer 1683 Luis Nicolas Gonzalez Castro, Tracy T. Batchelor, and Lisa M. DeAngelis 125 Dermatologic complications of cancer chemotherapy 1701 Anisha B. Patel, Padmavathi V. Karri, and Madeleine Duvic 126 Skeletal complications 1715 Michael A. Via, Ilya Iofin, Jerry Liu, and Jeffrey I. Mechanick 127 Hematologic complications and blood bank support 1729 Roger Belizaire and Kenneth C. Anderson 128 Coagulation complications of cancer patients 1739 Tzu-FeiWang and Kristin Sanfilippo 129 Urologic complications related to cancer and its treatment 1747 Omar Alhalabi, Ala Abudayyeh, and Nizar M. Tannir 130 Cardiac complications 1757 Michael S. Ewer, Steven M. Ewer, andThomas M. Suter 131 Respiratory complications 1779 Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez, Horiana B. Grosu, Rodolfo C. Morice, Lara Bashoura, Ajay Sheshadre, Scott E. Evans, Roberto Adachi, Michael Kroll, Saadia A. Faiz, Diwakar D. Balachandran, Selvaraj E. Pravinkumar, and Burton F. Dickey 132 Gastrointestinal and hepatic complications in cancer patients 1811 Robert S. Bresalier, Emmanuel S. Coronel, and Hao Chi Zhang 133 Oral complications of cancer and their treatment 1827 Stephen T. Sonis, Anna Yuan, and Alessandro Villa 134 Gonadal complications 1839 RobertW. Lentz and Catherine E. Klein 135 Sexual dysfunction 1849 Leslie R. Schover 136 Endocrine complications and paraneoplastic syndromes 1855 Sai-Ching J. Yeung and Robert F. Gagel 137 Infections in patients with cancer 1869 Harrys A. Torres, Dimitrios P. Kontoyiannis, and Kenneth V.I. Rolston 138 Oncologic emergencies 1883 Sai-Ching J. Yeung and Carmen P. Escalante Part 13: THE FUTURE OF ONCOLOGY 139 A vision for twenty-first century healthcare 1907 Leroy Hood, Nathan D. Price, and James T. Yurkovich Index 1915

Holland-Frei Cancer Medicine (10 ed)