Peritoneal Tumor Microenvironment of Cancers on Cancer Hallmarks: Perspectives of Translational Medicine provides readers with cutting-edge knowledge on tumor microenvironment. By exploring multiple aspects on tumor microenvironment, it gives an integrative insight on cancer diseases ranging from diagnosis to prediction of prognosis and individualized treatment. The book discusses topics such as clinical significance of tumor microenvironment, tumorigenesis and cancer progression, histopathological features of cancer in peritoneum, immune cells in tumor, exosomal cell-to-cell interactions, and therapeutic approaches to target tumor microenvironment. In addition, it discusses tumor evolution during chemotherapy and metastasis and future perspectives on identification and validation of biomarkers using liquid biopsy. This book is a valuable resource for cancer researchers, oncologists, medical doctors, and several members of biomedical field who want to understand the complex microenvironment of peritoneal tumors.
1. What is tumor microenvironment?
2. Clinical significance in cancers
3. Tumor microenvironment of peritoneal cancer: the concept of premetastatic niche altered before tumor implantation
4. Tumorigenesis and progression of cancer
5. Histopathological features of cancer in peritoneum
6. Metabolism of cancer cells altered in peritoneal tumor microenvironment
7. Cancer stem cells: Dormancy and chemoresistance
8. Immune cells in tumor microenvironment
9. Fibroblasts in tumor microenvironment
10. Cytokine and chemokines in tumor microenvironment
11. Exosomal cell-to-cell interactions in tumor microenvironment
12. Development of diagnostic/prognostic/therapeutic biomarkers
13. Therapeutic approaches targeting tumor microenvironment
14. The concept of xenograft with difference between cancer cell (human) and microenvironment (mice)
15. Tumor organoids model for validation of biomarkers critical for cancer progression
16. Innovative technology to decipher tumoral heterogeneity of peritoneal cancers
17. Tumor evolution during chemotherapy
18. Tumor evolution during metastasis
19. Modulation of tumor microenvironment: (1) Pressure (PIPEC), hydration/temperature (Coelioscopy procedure) and light (photodynamic therapy)
20. Modulation of tumor microenvironment: (2) Surgery
21. Modulation of tumor microenvironment: (3) Radiation
22. Future perspective: Identification and validation of biomarkers using liquid biopsy
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